Atp8b4 MGI Mouse Gene Detail - MGI:1859664 - ATPase, class I, type 8B, member 4

Symbol

Atp8b4
Name

ATPase, class I, type 8B, member 4
Synonyms

Im

Feature Type

protein coding gene
IDs

MGI:1859664
NCBI Gene: 241633
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr2:126162893-126342589 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.76 cM
Mapping Data

1 experiment

SNPs within 2kb

4564 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859664	protein coding gene	Chr2:126162893-126342594 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026439	protein coding gene	Chr2:129519338-129717095 (-)
A/J	MGP_AJ_G0026402	protein coding gene	Chr2:124273439-124456587 (-)
AKR/J	MGP_AKRJ_G0026378	protein coding gene	Chr2:127838832-128023751 (-)
BALB/cJ	MGP_BALBcJ_G0026414	protein coding gene	Chr2:124547916-124728015 (-)
C3H/HeJ	MGP_C3HHeJ_G0026158	protein coding gene	Chr2:128320102-128508346 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026860	protein coding gene	Chr2:133658813-133850550 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024237	protein coding gene	Chr2:119006686-119186134 (-)
CAST/EiJ	MGP_CASTEiJ_G0025619	protein coding gene	Chr2:128547526-128740837 (-)
CBA/J	MGP_CBAJ_G0026138	protein coding gene	Chr2:138541109-138743053 (-)
DBA/2J	MGP_DBA2J_G0026272	protein coding gene	Chr2:123683307-123870507 (-)
FVB/NJ	MGP_FVBNJ_G0026236	protein coding gene	Chr2:122347940-122525070 (-)
LP/J	MGP_LPJ_G0026377	protein coding gene	Chr2:129781181-129972344 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026256	protein coding gene	Chr2:142609808-142820161 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026915	protein coding gene	Chr2:127855539-128043454 (-)
PWK/PhJ	MGP_PWKPhJ_G0025355	protein coding gene	Chr2:123227935-123414684 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025157	protein coding gene	Chr2:126921303-127111422 (-)
WSB/EiJ	MGP_WSBEiJ_G0025693	protein coding gene	Chr2:128747996-128935788 (-)

Human Ortholog

ATP8B4, ATPase phospholipid transporting 8B4 (putative)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATP8B4, ATPase phospholipid transporting 8B4 (putative)
Synonyms

ATPIM
Links

HGNC:13536

NCBI Gene ID: 79895

neXtProt AC: NX_Q8TF62

UniProt: Q8TF62
Chr Location

15q21.2; chr15:49858238-50182817 (-) GRCh38

MGI Vertebrate Homology

Atp8b4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATP8B4
Gene Tree

Atp8b4

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Atp8b4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

18

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atp8b4

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All Sequences

55
RefSeq

12
UniProt

5
CCDS

CCDS50698.1

Ensembl

ENSMUSG00000060131 (Evidence)
NCBI Gene

241633

			Length	Strain/Species	Flank
genomic	241633	NCBI Gene Model \| MGI Sequence Detail	179697	C57BL/6J	± kb
transcript	NM_001359975	RefSeq \| MGI Sequence Detail	5693	C57BL/6
polypeptide	NP_001346904	RefSeq \| MGI Sequence Detail	1194	C57BL/6

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UniProt

5 Sequences
EC

7.6.2.1
InterPro Domains

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR001757 P-type ATPase

IPR008250 P-type ATPase, A domain superfamily

IPR032630 P-type ATPase, C-terminal

IPR023299 P-type ATPase, cytoplasmic domain N

IPR044492 P-type ATPase, haloacid dehalogenase domain

IPR032631 P-type ATPase, N-terminal

IPR018303 P-type ATPase, phosphorylation site

IPR006539 P-type ATPase, subfamily IV

IPR023298 P-type ATPase, transmembrane domain superfamily

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All nucleic 19

Genomic 1

cDNA 18

Microarray probesets 2

Summaries

All 27

Gene Ontology 2

Phenotypes 9
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Atp8b4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26046	Chr2:126342551-126342595 (-)	16 bp
Tssr26045	Chr2:126342212-126342214 (-)	376 bp
Tssr26044	Chr2:126341834-126341852 (-)	746 bp
Tssr26043	Chr2:126341759-126341778 (-)	820 bp
Tssr26042	Chr2:126341696-126341714 (-)	884 bp
Tssr26041	Chr2:126341651-126341662 (-)	932 bp
Tssr26040	Chr2:126341634-126341645 (-)	949 bp
Tssr26039	Chr2:126341601-126341632 (-)	972 bp
Tssr26038	Chr2:126340081-126340094 (-)	2,501 bp
Tssr26037	Chr2:126333486-126333502 (-)	9,095 bp
Tssr26036	Chr2:126333453-126333478 (-)	9,123 bp
Tssr26035	Chr2:126331949-126331962 (-)	10,633 bp
Tssr26034	Chr2:126302556-126302562 (-)	40,030 bp
Tssr26033	Chr2:126163480-126163490 (-)	179,104 bp
Tssr26032	Chr2:126163385-126163395 (-)	179,199 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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