Rgs14 MGI Mouse Gene Detail - MGI:1859709 - regulator of G-protein signaling 14

Symbol

Rgs14
Name

regulator of G-protein signaling 14
Synonyms

Rap1/rap2 interacting protein

Feature Type

protein coding gene
IDs

MGI:1859709
NCBI Gene: 51791
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:55517545-55532500 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 29.80 cM
Mapping Data

2 experiments

SNPs within 2kb

378 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859709	protein coding gene	Chr13:55517269-55532504 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020593	protein coding gene	Chr13:54846028-54861413 (+)
A/J	MGP_AJ_G0020547	protein coding gene	Chr13:52820015-52834992 (+)
AKR/J	MGP_AKRJ_G0020525	protein coding gene	Chr13:54373566-54388477 (+)
BALB/cJ	MGP_BALBcJ_G0020543	protein coding gene	Chr13:53048961-53063950 (+)
C3H/HeJ	MGP_C3HHeJ_G0020342	protein coding gene	Chr13:54191798-54207159 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020977	protein coding gene	Chr13:56498300-56513235 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018559	protein coding gene	Chr13:50768997-50784310 (+)
CAST/EiJ	MGP_CASTEiJ_G0019856	protein coding gene	Chr13:54292005-54307042 (+)
CBA/J	MGP_CBAJ_G0020302	protein coding gene	Chr13:58664779-58679982 (+)
DBA/2J	MGP_DBA2J_G0020425	protein coding gene	Chr13:52371520-52386866 (+)
FVB/NJ	MGP_FVBNJ_G0020404	protein coding gene	Chr13:51840503-51855404 (+)
LP/J	MGP_LPJ_G0020501	protein coding gene	Chr13:55104540-55119542 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020433	protein coding gene	Chr13:58136803-58151733 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021020	protein coding gene	Chr13:53965235-53980350 (+)
PWK/PhJ	MGP_PWKPhJ_G0019612	protein coding gene	Chr13:52397614-52416390 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019439	protein coding gene	Chr13:52884021-52900622 (+)
WSB/EiJ	MGP_WSBEiJ_G0019918	protein coding gene	Chr13:54322085-54337082 (+)

Human Ortholog

RGS14, regulator of G protein signaling 14

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RGS14, regulator of G protein signaling 14
Links

HGNC:9996

NCBI Gene ID: 10636

neXtProt AC: NX_O43566

UniProt: O43566
Chr Location

5q35.3; chr5:177357924-177372596 (+) GRCh38

MGI Vertebrate Homology

Rgs14 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RGS14
Gene Tree

Rgs14

Diseases

1 with human RGS14 associations

				Human Disease	Mouse Models
				nephrolithiasis IDs nephrolithiasis DOID:585 EFO:0004253 ICD10CM:N20 ICD9CM:592 UMLS_CUI:C0156257

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

20 phenotypes from 2 alleles in 3 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

6
Genomic Mutations

2 involving Rgs14
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygosity for one knockout allele results in failure to complete the first zygotic cell division. Another homozygous KO affects long-term potentiation in hippocampal neurons which leads to enhanced spatial learning and long-term memory. A third homozygous KO results in no obvious phenotype.

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All GO Annotations

78
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

24
cDNA Data

11
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgs14

ZFIN rgs14a

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All Sequences

38
RefSeq

6
UniProt

2
CCDS

CCDS36674.1

Ensembl

ENSMUSG00000052087 (Evidence)
NCBI Gene

51791

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052087	Ensembl Gene Model \| MGI Sequence Detail	14956	C57BL/6J	± kb
transcript	ENSMUST00000063771	Ensembl \| MGI Sequence Detail	2356	Not Applicable
polypeptide	ENSMUSP00000068731	Ensembl \| MGI Sequence Detail	547	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013949 regulator of G-protein signaling 14

(term hierarchy)
PDB

1WFY
InterPro Domains

IPR003109 GoLoco motif

IPR003116 Raf-like Ras-binding

IPR046995 Regulator of G-protein signaling 10/12/14-like

IPR046992 Regulator of G-protein signaling 14, Ras-binding domain 1

IPR046993 Regulator of G protein signaling 14, Ras-binding domain 2

IPR037881 RGS14, RGS domain

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR024066 RGS, subdomain 1/3

IPR044926 RGS, subdomain 2

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 11

cDNA 11

Microarray probesets 3

Summaries

All 59

Developmental Gene Expression 7

Diseases 1

Gene Ontology 15

Phenotypes 21
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:350529 Samadi M, et al., Mechanisms of mGluR-dependent plasticity in hippocampal area CA2. Hippocampus. 2023 Jun;33(6):730-744

TSS for Rgs14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119942	Chr13:55517549-55517579 (+)	19 bp
Tssr119943	Chr13:55517580-55517588 (+)	39 bp
Tssr119944	Chr13:55517594-55517626 (+)	65 bp
Tssr119945	Chr13:55526982-55526992 (+)	9,442 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24