About   Help   FAQ
Hif3a Gene Detail
Summary
  • Symbol
    Hif3a
  • Name
    hypoxia inducible factor 3, alpha subunit
  • Synonyms
    bHLHe17, MOP7, Nepas
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859778
    NCBI Gene: 53417
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:16765432-16796352 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.15 cM, cytoband A2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    926 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859778
 protein coding gene Chr7:16764918-16796352 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031728
 protein coding gene Chr7:14809320-14844258 (-)
A/J MGP_AJ_G0031700
 protein coding gene Chr7:14512661-14544956 (-)
AKR/J MGP_AKRJ_G0031625
 protein coding gene Chr7:14857922-14889512 (-)
BALB/cJ MGP_BALBcJ_G0031707
 protein coding gene Chr7:14625617-14659257 (-)
C3H/HeJ MGP_C3HHeJ_G0031429
 protein coding gene Chr7:15046484-15082639 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032173
 protein coding gene Chr7:15534479-15565514 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029252
 protein coding gene Chr7:16063016-16093267 (-)
CAST/EiJ MGP_CASTEiJ_G0030780
 protein coding gene Chr7:11824339-11859789 (-)
CBA/J MGP_CBAJ_G0031388
 protein coding gene Chr7:16067359-16110214 (-)
DBA/2J MGP_DBA2J_G0031544
 protein coding gene Chr7:14410579-14441829 (-)
FVB/NJ MGP_FVBNJ_G0031500
 protein coding gene Chr7:14309102-14341431 (-)
LP/J MGP_LPJ_G0031629
 protein coding gene Chr7:15053522-15097556 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031535
 protein coding gene Chr7:15979153-16014959 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032202
 protein coding gene Chr7:14643617-14689715 (-)
PWK/PhJ MGP_PWKPhJ_G0030504
 protein coding gene Chr7:11929616-11966510 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030331
 protein coding gene Chr7:9570411-9604833 (-)
WSB/EiJ MGP_WSBEiJ_G0030877
 protein coding gene Chr7:14706706-14746369 (-)



Homology
more
  • Human Ortholog
    HIF3A, hypoxia inducible factor 3 subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HIF3A, hypoxia inducible factor 3 subunit alpha
  • Synonyms
    bHLHe17, HIF-3A, HIF3-alpha-1, IPAS, MOP7, PASD7
  • Links
    NCBI Gene ID: 64344
    neXtProt AC: NX_Q9Y2N7
    UniProt: Q9Y2N7

  • Chr Location
    19q13.32; chr19:46297042-46343433 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display impaired lung remodeling resulting in hypertrophy of the heart right ventricle and pulmonary hyperplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    73
  • cDNA Data
    30
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004328 Ensembl Gene Model | MGI Sequence Detail 30921 C57BL/6J ±  kb
    transcript ENSMUST00000108492 Ensembl | MGI Sequence Detail 6402 Not Applicable  
    polypeptide ENSMUSP00000104132 Ensembl | MGI Sequence Detail 664 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 30
      Primer pair 2
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 17
      Gene Ontology 11
      Phenotypes 6
    • Earliest
      J:62516 Gu YZ, et al., Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr. 1998;7(3):205-13
    • Latest
      J:351082 Kawahata T, et al., HIF3A gene disruption causes abnormal alveoli structure and early neonatal death. PLoS One. 2024;19(5):e0300751
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory