Prdx5 MGI Mouse Gene Detail - MGI:1859821

Symbol

Prdx5
Name

peroxiredoxin 5
Synonyms

AOEB166, AOPP, peroxiredoxin V, PMP20, Prdx6, PrxV, PrxV

Feature Type

protein coding gene
IDs

MGI:1859821
NCBI Gene: 54683
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr19:6884065-6887474 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.08 cM
Mapping Data

3 experiments

SNPs within 2kb

124 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859821	protein coding gene	Chr19:6884065-6887474 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024768	protein coding gene	Chr19:3996444-3999853 (-)
A/J	MGP_AJ_G0024734	protein coding gene	Chr19:3667372-3670781 (-)
AKR/J	MGP_AKRJ_G0024707	protein coding gene	Chr19:3783633-3787042 (-)
BALB/cJ	MGP_BALBcJ_G0024734	protein coding gene	Chr19:3777124-3780533 (-)
C3H/HeJ	MGP_C3HHeJ_G0024502	protein coding gene	Chr19:3910505-3913914 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025180	protein coding gene	Chr19:4083504-4086913 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022614	protein coding gene	Chr19:3576894-3580384 (-)
CAST/EiJ	MGP_CASTEiJ_G0023974	protein coding gene	Chr19:3818932-3822340 (-)
CBA/J	MGP_CBAJ_G0024474	protein coding gene	Chr19:4130982-4134390 (-)
DBA/2J	MGP_DBA2J_G0024601	protein coding gene	Chr19:3641581-3644989 (-)
FVB/NJ	MGP_FVBNJ_G0024567	protein coding gene	Chr19:3669709-3673118 (-)
LP/J	MGP_LPJ_G0024687	protein coding gene	Chr19:3855899-3859308 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024596	protein coding gene	Chr19:4041215-4044624 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025228	protein coding gene	Chr19:3918084-3921493 (-)
PWK/PhJ	MGP_PWKPhJ_G0023720	protein coding gene	Chr19:3683585-3686996 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023525	protein coding gene	Chr19:3737206-3740603 (-)
WSB/EiJ	MGP_WSBEiJ_G0024036	protein coding gene	Chr19:3814689-3818099 (-)

Human Ortholog

PRDX5, peroxiredoxin 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRDX5, peroxiredoxin 5
Synonyms

ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, prx-V, PRXV, SBBI10
Links

HGNC:9355

NCBI Gene ID: 25824

neXtProt AC: NX_P30044

UniProt: P30044
Chr Location

11q13.1; chr11:64318121-64321811 (+) GRCh38

MGI Vertebrate Homology

Prdx5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRDX5
Gene Tree

Prdx5

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Phenotype Summary

25 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

2
Targeted

5
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show increased susceptibility to high fat diet-induced obesity and hepatic steatosis. Mice homozygous for a different null allele show elevated nitric oxide production and oxidative stress in bone-marrow-derived dendritic cells.

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All GO Annotations

51
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

77
cDNA Data

249
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prdx5

ZFIN prdx5

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All Sequences

57
RefSeq

4
UniProt

9
CCDS

CCDS29507.1

Ensembl

ENSMUSG00000024953 (Evidence)
NCBI Gene

54683

			Length	Strain/Species	Flank
genomic	54683	NCBI Gene Model \| MGI Sequence Detail	3410	C57BL/6J	± kb
transcript	NM_012021	RefSeq \| MGI Sequence Detail	1271	ZRU/MplStud
polypeptide	P99029	UniProt \| EBI \| MGI Sequence Detail	210	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000013195 peroxiredoxin-5, mitochondrial

(term hierarchy)
EC

1.11.1.24
InterPro Domains

IPR037944 Peroxiredoxin-5-like

IPR013740 Redoxin

IPR013766 Thioredoxin domain

IPR036249 Thioredoxin-like superfamily
GlyGen

P99029 1 site, 1 O-linked glycan (1 site)

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All nucleic 250

cDNA 249

Primer pair 1

Microarray probesets 2

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MGI:1349456

Summaries

All 65

Developmental Gene Expression 9

Gene Ontology 10

Phenotypes 13
Earliest

J:58008 Yamashita H, et al., Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro. J Biol Chem. 1999 Oct 15;274(42):29897-904
Latest

J:344186 Munoz-Gallardo MDM, et al., miR-195b is required for proper cellular homeostasis in the elderly. Sci Rep. 2024 Jan 8;14(1):810

TSS for Prdx5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157894	Chr19:6887502-6887510 (-)	-32 bp
Tssr157893	Chr19:6887456-6887493 (-)	-1 bp
Tssr157892	Chr19:6887435-6887450 (-)	31 bp
Tssr157891	Chr19:6887302-6887383 (-)	131 bp
Tssr157890	Chr19:6887001-6887059 (-)	444 bp
Tssr157889	Chr19:6886967-6886994 (-)	493 bp
Tssr157888	Chr19:6886932-6886964 (-)	526 bp
Tssr157887	Chr19:6886223-6886236 (-)	1,244 bp
Tssr157886	Chr19:6885657-6885678 (-)	1,806 bp
Tssr157885	Chr19:6885472-6885485 (-)	1,995 bp
Tssr157884	Chr19:6885376-6885404 (-)	2,084 bp
Tssr157883	Chr19:6885132-6885146 (-)	2,335 bp
Tssr157882	Chr19:6885070-6885080 (-)	2,399 bp
Tssr157881	Chr19:6885034-6885066 (-)	2,424 bp
Tssr157880	Chr19:6884282-6884306 (-)	3,180 bp
Tssr157879	Chr19:6884247-6884260 (-)	3,220 bp
Tssr157878	Chr19:6884220-6884246 (-)	3,241 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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