Fezf2 MGI Mouse Gene Detail - MGI:1859823

Symbol

Fezf2
Name

Fez family zinc finger 2
Synonyms

Fez, Fezl, forebrain embryonic zinc finger, Zfp312

Feature Type

protein coding gene
IDs

MGI:1859823
NCBI Gene: 54713
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr14:10121574-10127669 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 6.36 cM
Mapping Data

2 experiments

SNPs within 2kb

118 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859823	protein coding gene	Chr14:10121561-10130771 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020999	protein coding gene	Chr14:4753142-4758760 (-)
A/J	MGP_AJ_G0020947	protein coding gene	Chr14:4663758-4667731 (-)
AKR/J	MGP_AKRJ_G0020924	protein coding gene	Chr14:4742895-4746864 (-)
BALB/cJ	MGP_BALBcJ_G0020950	protein coding gene	Chr14:4653605-4657752 (-)
C3H/HeJ	MGP_C3HHeJ_G0020734	protein coding gene	Chr14:4775098-4779082 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021383	protein coding gene	Chr14:4930340-4937128 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018952	protein coding gene	Chr14:5393473-5397462 (-)
CAST/EiJ	MGP_CASTEiJ_G0020256	protein coding gene	Chr14:4765291-4769279 (-)
CBA/J	MGP_CBAJ_G0020700	protein coding gene	Chr14:5065707-5069677 (-)
DBA/2J	MGP_DBA2J_G0020823	protein coding gene	Chr14:4605378-4609362 (-)
FVB/NJ	MGP_FVBNJ_G0020805	protein coding gene	Chr14:4570602-4575005 (-)
LP/J	MGP_LPJ_G0020899	protein coding gene	Chr14:4719537-4724358 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020831	protein coding gene	Chr14:5165976-5169976 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021416	protein coding gene	Chr14:4721369-4725995 (-)
PWK/PhJ	MGP_PWKPhJ_G0020008	protein coding gene	Chr14:4612794-4617147 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019828	protein coding gene	Chr14:4775945-4779944 (-)
WSB/EiJ	MGP_WSBEiJ_G0020314	protein coding gene	Chr14:4745151-4749839 (-)

Human Ortholog

FEZF2, FEZ family zinc finger 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FEZF2, FEZ family zinc finger 2
Synonyms

FEZ, FEZL, FKSG36, TOF, ZFP312, ZNF312
Links

HGNC:13506

NCBI Gene ID: 55079

neXtProt AC: NX_Q8TBJ5

UniProt: Q8TBJ5
Chr Location

3p14.2; chr3:62369681-62374324 (-) GRCh38

MGI Vertebrate Homology

Fezf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FEZF2
Gene Tree

Fezf2

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Phenotype Summary

17 phenotypes from 5 alleles in 7 genetic backgrounds
15 phenotypes from multigenic genotypes
1 images
55 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

2
Gene trapped

1
Targeted

8
Transgenic

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for a null allele show hyperactivity, altered feeding behavior leading to delayed growth and premature death, and impaired formation of subplate neurons and thalamocortical projections. Homozygotes for another allele lack a corpus callosum and show severe subcortical projection defects.

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All GO Annotations

40
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1070
Tissues

192
cDNA Data

22
Literature Summary

89

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FEZF2

Xenbase fezf2

ZFIN fezf2

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All Sequences

44
RefSeq

6
UniProt

2
CCDS

CCDS26818.1

Ensembl

ENSMUSG00000021743 (Evidence)
NCBI Gene

54713

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021743	Ensembl Gene Model \| MGI Sequence Detail	6096	C57BL/6J	± kb
transcript	ENSMUST00000022262	Ensembl \| MGI Sequence Detail	2188	Not Applicable
polypeptide	ENSMUSP00000022262	Ensembl \| MGI Sequence Detail	455	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007469 fez family zinc finger protein 2

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 35

cDNA 23

Primer pair 5

Other 7

Microarray probesets 3

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MGI:2145654, MGI:2145702

Summaries

All 153

Developmental Gene Expression 89

Gene Ontology 13

Phenotypes 55
Earliest

J:62051 Matsuo-Takasaki M, et al., Cloning and expression of a novel zinc finger gene, Fez, transcribed in the forebrain of Xenopus and mouse embryos. Mech Dev. 2000 May;93(1-2):201-4
Latest

J:354227 Barao S, et al., Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion. Nat Commun. 2024 Sep 14;15(1):8043

TSS for Fezf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127462	Chr14:10123112-10123118 (+)	1,541 bp
Tssr127461	Chr14:10123647-10123669 (+)	2,084 bp
Tssr127460	Chr14:10123891-10123916 (+)	2,330 bp
Tssr127459	Chr14:10123930-10123954 (+)	2,368 bp
Tssr127458	Chr14:10123974-10123983 (+)	2,405 bp
Tssr127457	Chr14:10124023-10124036 (+)	2,456 bp
Tssr127456	Chr14:10124092-10124130 (+)	2,537 bp
Tssr127455	Chr14:10124508-10124518 (+)	2,939 bp
Tssr127454	Chr14:10124917-10124925 (+)	3,347 bp
Tssr127453	Chr14:10126014-10126033 (+)	4,450 bp
Tssr127452	Chr14:10126445-10126450 (+)	4,874 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24