Ebag9 MGI Mouse Gene Detail - MGI:1859920 - estrogen receptor-binding fragment-associated gene 9

Symbol

Ebag9
Name

estrogen receptor-binding fragment-associated gene 9
Synonyms

Rcas1

Feature Type

protein coding gene
IDs

MGI:1859920
NCBI Gene: 55960
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:44482571-44504911 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 16.91 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

566 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859920	protein coding gene	Chr15:44482571-44504916 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021832	protein coding gene	Chr15:43240640-43262550 (+)
A/J	MGP_AJ_G0021792	protein coding gene	Chr15:41596809-41618747 (+)
AKR/J	MGP_AKRJ_G0021773	protein coding gene	Chr15:42826052-42846821 (+)
BALB/cJ	MGP_BALBcJ_G0021799	protein coding gene	Chr15:41673728-41694884 (+)
C3H/HeJ	MGP_C3HHeJ_G0021573	protein coding gene	Chr15:42746844-42767520 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022238	protein coding gene	Chr15:44922876-44948381 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019775	protein coding gene	Chr15:39125105-39148096 (+)
CAST/EiJ	MGP_CASTEiJ_G0021090	protein coding gene	Chr15:43264856-43291449 (+)
CBA/J	MGP_CBAJ_G0021542	protein coding gene	Chr15:46471956-46494345 (+)
DBA/2J	MGP_DBA2J_G0021666	protein coding gene	Chr15:41400130-41421535 (+)
FVB/NJ	MGP_FVBNJ_G0021644	protein coding gene	Chr15:40702852-40723961 (+)
LP/J	MGP_LPJ_G0021736	protein coding gene	Chr15:43008625-43031900 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021668	protein coding gene	Chr15:49882131-49909297 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022261	protein coding gene	Chr15:43007519-43030096 (+)
PWK/PhJ	MGP_PWKPhJ_G0020835	protein coding gene	Chr15:41454933-41476742 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020672	protein coding gene	Chr15:42691285-42717259 (+)
WSB/EiJ	MGP_WSBEiJ_G0021145	protein coding gene	Chr15:42907087-42928549 (+)

Human Ortholog

EBAG9, estrogen receptor binding site associated antigen 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EBAG9, estrogen receptor binding site associated antigen 9
Synonyms

EB9, PDAF
Links

HGNC:3123

NCBI Gene ID: 9166

neXtProt AC: NX_O00559

UniProt: O00559
Chr Location

8q23.2; chr8:109539702-109570072 (+) GRCh38

MGI Vertebrate Homology

Ebag9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EBAG9
Protein SuperFamily

RCAS1
Gene Tree

Ebag9

Diseases

1 with human EBAG9 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
1 images
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

5
Targeted

5
Genomic Mutations

2 involving Ebag9
Incidental Mutations

APF
Find Mice (IMSR)

22 strains or lines available

Homozygous null mice have decreased susceptibility to bacterial infections and have CD8⁺ T cells with enhanced cytolytic activity.

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All GO Annotations

8
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

775
Tissues

44
cDNA Data

30
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ebag9

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All Sequences

50
RefSeq

8
UniProt

2
CCDS

CCDS27457.1

Ensembl

ENSMUSG00000022339 (Evidence)
NCBI Gene

55960

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022339	Ensembl Gene Model \| MGI Sequence Detail	22341	C57BL/6J	± kb
transcript	ENSMUST00000227691	Ensembl \| MGI Sequence Detail	1945	Not Applicable
polypeptide	ENSMUSP00000154361	Ensembl \| MGI Sequence Detail	213	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006866 receptor-binding cancer antigen expressed on SiSo cells

(term hierarchy)
InterPro Domains

IPR017025 Cancer-associated antigen RCAS1

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All nucleic 31

cDNA 30

Primer pair 1

Microarray probesets 3

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MGI:2146065

Summaries

All 50

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 17
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:351223 Azuma K, et al., EBAG9-deficient mice display decreased bone mineral density with suppressed autophagy. iScience. 2024 Feb 16;27(2):108871

TSS for Ebag9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131231	Chr15:44482545-44482588 (+)	-4 bp
Tssr131232	Chr15:44482620-44482638 (+)	58 bp
Tssr131233	Chr15:44482667-44482724 (+)	125 bp
Tssr131234	Chr15:44482947-44483026 (+)	416 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24