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Slc2a8 Gene Detail
Summary
  • Symbol
    Slc2a8
  • Name
    solute carrier family 2, (facilitated glucose transporter), member 8
  • Synonyms
    D2Ertd44e, GLUT8, GlutX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860103
    NCBI Gene: 56017
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32863002-32872095 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860103
 protein coding gene Chr2:32862993-32872095 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025629
 protein coding gene Chr2:31476317-31487515 (-)
A/J MGP_AJ_G0025606
 protein coding gene Chr2:30131345-30140420 (-)
AKR/J MGP_AKRJ_G0025576
 protein coding gene Chr2:31212272-31221363 (-)
BALB/cJ MGP_BALBcJ_G0025603
 protein coding gene Chr2:30251876-30260957 (-)
C3H/HeJ MGP_C3HHeJ_G0025363
 protein coding gene Chr2:31095596-31105093 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026047
 protein coding gene Chr2:32424696-32435101 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023456
 protein coding gene Chr2:28858117-28867408 (-)
CAST/EiJ MGP_CASTEiJ_G0024825
 protein coding gene Chr2:31057116-31067911 (-)
CBA/J MGP_CBAJ_G0025341
 protein coding gene Chr2:33668766-33677815 (-)
DBA/2J MGP_DBA2J_G0025474
 protein coding gene Chr2:29895738-29904826 (-)
FVB/NJ MGP_FVBNJ_G0025436
 protein coding gene Chr2:29786617-29796821 (-)
LP/J MGP_LPJ_G0025560
 protein coding gene Chr2:31361697-31370763 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025467
 protein coding gene Chr2:33260662-33269741 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026105
 protein coding gene Chr2:31085584-31094677 (-)
PWK/PhJ MGP_PWKPhJ_G0024573
 protein coding gene Chr2:29809645-29818791 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024373
 protein coding gene Chr2:31244990-31259469 (-)
WSB/EiJ MGP_WSBEiJ_G0024894
 protein coding gene Chr2:31273424-31284243 (-)



Homology
more
  • Human Ortholog
    SLC2A8, solute carrier family 2 member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC2A8, solute carrier family 2 member 8
  • Synonyms
    GLUT8, GLUTX1
  • Links
    NCBI Gene ID: 29988
    neXtProt AC: NX_Q9NY64
    UniProt: Q9NY64

  • Chr Location
    9q33.3; chr9:127397138-127408424 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for one null allele show reduced spermatozoan ATP levels, mitochondrial membrane potential and sperm motility, and a slight deviation from the expected Mendelian frequency. Homozygotes for another null allele show increased hippocampus cell proliferation and cardiac P-wave duration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    846
  • Tissues
    110
  • cDNA Data
    42
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026791 Ensembl Gene Model | MGI Sequence Detail 9094 C57BL/6J ±  kb
    transcript ENSMUST00000028129 Ensembl | MGI Sequence Detail 2108 Not Applicable  
    polypeptide ENSMUSP00000028129 Ensembl | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000015071 solute carrier family 2, facilitated glucose transporter member 8
      (term hierarchy)
    • InterPro Domains
      IPR005828 Major facilitator, sugar transporter-like
      IPR020846 Major facilitator superfamily domain
      IPR050549 Major Facilitator Superfamily Trehalose Transporter
      IPR036259 MFS transporter superfamily
      IPR003663 Sugar/inositol transporter
      IPR005829 Sugar transporter, conserved site
    • GlyGen
      Q9JIF3 1 site
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 42
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1098576
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory