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Pfpl Gene Detail
Summary
  • Symbol
    Pfpl
  • Name
    pore forming protein-like
  • Synonyms
    Epcs5, Epcs50
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860266
    NCBI Gene: 56093
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:12405290-12409474 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 8.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860266
 protein coding gene Chr19:12405269-12409474 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024904
 protein coding gene Chr19:9894471-9898676 (+)
A/J MGP_AJ_G0024880
 protein coding gene Chr19:9269836-9274041 (+)
AKR/J MGP_AKRJ_G0024852
 protein coding gene Chr19:9730081-9734286 (+)
BALB/cJ MGP_BALBcJ_G0024879
 protein coding gene Chr19:9267192-9271397 (+)
C3H/HeJ MGP_C3HHeJ_G0024643
 protein coding gene Chr19:9620222-9624427 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025328
 protein coding gene Chr19:10438204-10442409 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022754
 protein coding gene Chr19:9907025-9911221 (+)
CAST/EiJ MGP_CASTEiJ_G0024112
 protein coding gene Chr19:9195902-9200108 (+)
CBA/J MGP_CBAJ_G0024617
 protein coding gene Chr19:10516485-10520690 (+)
DBA/2J MGP_DBA2J_G0024749
 protein coding gene Chr19:9306403-9310608 (+)
FVB/NJ MGP_FVBNJ_G0024712
 protein coding gene Chr19:9333230-9337435 (+)
LP/J MGP_LPJ_G0024832
 protein coding gene Chr19:9967220-9971425 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024739
 protein coding gene Chr19:10298950-10303155 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025376
 protein coding gene Chr19:9699011-9703216 (+)
PWK/PhJ MGP_PWKPhJ_G0023861
 protein coding gene Chr19:8773732-8777939 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023665
 protein coding gene Chr19:8847610-8851816 (+)
WSB/EiJ MGP_WSBEiJ_G0024180
 protein coding gene Chr19:9570391-9574595 (+)



Homology
more
  • Human Ortholog
    MPEG1, macrophage expressed 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPEG1, macrophage expressed 1
  • Synonyms
    IMD77, Mpg-1, MPG1, MPS1, P-2
  • Links
    NCBI Gene ID: 219972
    neXtProt AC: NX_Q2M385
    UniProt: Q2M385

  • Chr Location
    11q12.1; chr11:59208510-59212927 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MPEG1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    12
  • cDNA Data
    33
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56093 NCBI Gene Model | MGI Sequence Detail 4185 C57BL/6J ±  kb
transcript NM_019540 RefSeq | MGI Sequence Detail 3897 C57BL/6  
polypeptide NP_062413 RefSeq | MGI Sequence Detail 702 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR039707 Macrophage-expressed gene 1 protein
    IPR020864 Membrane attack complex component/perforin (MACPF) domain
Molecular
Reagents
less
  • All nucleic 35
    cDNA 33
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 18
    Developmental Gene Expression 3
    Gene Ontology 2
  • Earliest
    J:62506 Hemberger M, et al., cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion. Dev Biol. 2000 Jun 1;222(1):158-69
  • Latest
    J:187742 Mould A, et al., Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta. Genes Dev. 2012 Sep 15;26(18):2063-74
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory