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Cts8 Gene Detail
Summary
  • Symbol
    Cts8
  • Name
    cathepsin 8
  • Synonyms
    CTS2, Epcs68, Epcs70
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860275
    NCBI Gene: 56094
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:61394561-61403162 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 32.68 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860275
 protein coding gene Chr13:61394559-61403172 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020660
 protein coding gene Chr13:61046200-61056483 (-)
A/J MGP_AJ_G0020615
 protein coding gene Chr13:58790105-58798559 (-)
AKR/J MGP_AKRJ_G0020590
 protein coding gene Chr13:60537353-60545954 (-)
BALB/cJ MGP_BALBcJ_G0020611
 protein coding gene Chr13:59007011-59015612 (-)
C3H/HeJ MGP_C3HHeJ_G0020408
 protein coding gene Chr13:60302094-60310695 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021045
 protein coding gene Chr13:62899543-62908330 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018626
 protein coding gene Chr13:56598481-56606891 (-)
CAST/EiJ MGP_CASTEiJ_G0019924
 protein coding gene Chr13:60538207-60546661 (-)
CBA/J MGP_CBAJ_G0020368
 protein coding gene Chr13:65248222-65256823 (-)
DBA/2J MGP_DBA2J_G0020492
 protein coding gene Chr13:58314303-58322904 (-)
FVB/NJ MGP_FVBNJ_G0020470
 protein coding gene Chr13:57810423-57818976 (-)
LP/J MGP_LPJ_G0020568
 protein coding gene Chr13:61269391-61278005 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020500
 protein coding gene Chr13:64497082-64505683 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021088
 protein coding gene Chr13:60108850-60117451 (-)
PWK/PhJ MGP_PWKPhJ_G0019677
 protein coding gene Chr13:58374097-58384747 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019506
 protein coding gene Chr13:59078213-59086643 (-)
WSB/EiJ MGP_WSBEiJ_G0019985
 protein coding gene Chr13:60580238-60590557 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    32
  • cDNA Data
    9
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56094 NCBI Gene Model | MGI Sequence Detail 8602 C57BL/6J ±  kb
transcript NM_019541 RefSeq | MGI Sequence Detail 2493 C57BL/6  
polypeptide Q9JI81 UniProt | EBI | MGI Sequence Detail 333 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
    3.4.22.-
  • InterPro Domains
    IPR013201 Cathepsin propeptide inhibitor domain (I29)
    IPR025660 Cysteine peptidase, histidine active site
    IPR039417 Papain-like cysteine endopeptidase
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR013128 Peptidase C1A
    IPR000668 Peptidase C1A, papain C-terminal
  • GlyGen
    Q9JI81 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 16
    Genomic 1
    cDNA 10
    Primer pair 4
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:315981 Torregrosa-Carrion R, et al., Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development. Sci Adv. 2021 Nov 12;7(46):eabj5445
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory