Ramp3 MGI Mouse Gene Detail - MGI:1860292 - receptor (calcitonin) activity modifying protein 3

Symbol

Ramp3
Name

receptor (calcitonin) activity modifying protein 3

Feature Type

protein coding gene
IDs

MGI:1860292
NCBI Gene: 56089
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:6608521-6627475 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 4.61 cM
Mapping Data

3 experiments

SNPs within 2kb

578 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860292	protein coding gene	Chr11:6608507-6627478 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018030	protein coding gene	Chr11:3809960-3828753 (+)
A/J	MGP_AJ_G0018003	protein coding gene	Chr11:3637744-3656534 (+)
AKR/J	MGP_AKRJ_G0017967	protein coding gene	Chr11:3819773-3838458 (+)
BALB/cJ	MGP_BALBcJ_G0017971	protein coding gene	Chr11:3646770-3665586 (+)
C3H/HeJ	MGP_C3HHeJ_G0017784	protein coding gene	Chr11:3703053-3725500 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018423	protein coding gene	Chr11:3899846-3918688 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016081	protein coding gene	Chr11:3524720-3544257 (+)
CAST/EiJ	MGP_CASTEiJ_G0017346	protein coding gene	Chr11:3695102-3716585 (+)
CBA/J	MGP_CBAJ_G0017759	protein coding gene	Chr11:4343748-4365024 (+)
DBA/2J	MGP_DBA2J_G0017869	protein coding gene	Chr11:3546813-3565934 (+)
FVB/NJ	MGP_FVBNJ_G0017861	protein coding gene	Chr11:3576412-3601456 (+)
LP/J	MGP_LPJ_G0017940	protein coding gene	Chr11:3870734-3889310 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017887	protein coding gene	Chr11:3884639-3903514 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018463	protein coding gene	Chr11:3845956-3866903 (+)
PWK/PhJ	MGP_PWKPhJ_G0017126	protein coding gene	Chr11:3587609-3606462 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016923	protein coding gene	Chr11:3793820-3812235 (+)
WSB/EiJ	MGP_WSBEiJ_G0017400	protein coding gene	Chr11:3677640-3696333 (+)

Human Ortholog

RAMP3, receptor activity modifying protein 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAMP3, receptor activity modifying protein 3
Links

HGNC:9845

NCBI Gene ID: 10268

neXtProt AC: NX_O60896

UniProt: O60896
Chr Location

7p13; chr7:45157791-45186302 (+) GRCh38

MGI Vertebrate Homology

Ramp3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RAMP3
Gene Tree

Ramp3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

4
Gene trapped

5
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased body weight at 6 months of age.

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All GO Annotations

62
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

781
Tissues

36
cDNA Data

18
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ramp3

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All Sequences

33
RefSeq

4
UniProt

1
CCDS

CCDS24425.1

Ensembl

ENSMUSG00000041046 (Evidence)
NCBI Gene

56089

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041046	Ensembl Gene Model \| MGI Sequence Detail	18955	C57BL/6J	± kb
transcript	ENSMUST00000045374	Ensembl \| MGI Sequence Detail	1233	Not Applicable
polypeptide	ENSMUSP00000047518	Ensembl \| MGI Sequence Detail	147	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013707 receptor activity-modifying protein 3

(term hierarchy)
InterPro Domains

IPR038126 RAMP domain superfamily

IPR006985 Receptor activity modifying protein
GlyGen

Q9WUP1 4 sites, 1 N-linked glycan (1 site)

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All nucleic 19

cDNA 19

Microarray probesets 3

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MGI:2144304

Summaries

All 56

Developmental Gene Expression 10

Gene Ontology 8

Phenotypes 18
Earliest

J:61899 Ono Y, et al., Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis. Biochem Biophys Res Commun. 2000 Apr 29;271(1):197-202
Latest

J:338821 Li R, et al., TRIM28 modulates nuclear receptor signaling to regulate uterine function. Nat Commun. 2023 Aug 1;14(1):4605

TSS for Ramp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100282	Chr11:6608510-6608574 (+)	21 bp
Tssr100283	Chr11:6622694-6622696 (+)	14,174 bp
Tssr100284	Chr11:6626771-6626782 (+)	18,256 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24