Tamalin MGI Mouse Gene Detail - MGI:1860303 - trafficking regulator and scaffold protein tamalin

Symbol

Tamalin
Name

trafficking regulator and scaffold protein tamalin
Synonyms

Grasp, tamalin

Feature Type

protein coding gene
IDs

MGI:1860303
NCBI Gene: 56149
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:101122088-101130637 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.57 cM, cytoband F3
Mapping Data

1 experiment

SNPs within 2kb

191 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860303	protein coding gene	Chr15:101122069-101130637 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022367	protein coding gene	Chr15:103272613-103280968 (+)
A/J	MGP_AJ_G0022329	protein coding gene	Chr15:99187347-99195730 (+)
AKR/J	MGP_AKRJ_G0022305	protein coding gene	Chr15:102209430-102217754 (+)
BALB/cJ	MGP_BALBcJ_G0022333	protein coding gene	Chr15:99289641-99298026 (+)
C3H/HeJ	MGP_C3HHeJ_G0022103	protein coding gene	Chr15:102296389-102304716 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022781	protein coding gene	Chr15:107114413-107122875 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020306	protein coding gene	Chr15:94923049-94931384 (+)
CAST/EiJ	MGP_CASTEiJ_G0021628	protein coding gene	Chr15:103147663-103157296 (+)
CBA/J	MGP_CBAJ_G0022072	protein coding gene	Chr15:110826772-110838349 (+)
DBA/2J	MGP_DBA2J_G0022199	protein coding gene	Chr15:98519696-98528076 (+)
FVB/NJ	MGP_FVBNJ_G0022178	protein coding gene	Chr15:97568925-97577281 (+)
LP/J	MGP_LPJ_G0022270	protein coding gene	Chr15:103411064-103421109 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022199	protein coding gene	Chr15:114520875-114529201 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022795	protein coding gene	Chr15:102234818-102245282 (+)
PWK/PhJ	MGP_PWKPhJ_G0021367	protein coding gene	Chr15:98675027-98683370 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021199	protein coding gene	Chr15:102130429-102140529 (+)
WSB/EiJ	MGP_WSBEiJ_G0021678	protein coding gene	Chr15:102858250-102866525 (+)

Human Ortholog

TAMALIN, trafficking regulator and scaffold protein tamalin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAMALIN, trafficking regulator and scaffold protein tamalin
Synonyms

GRASP
Links

HGNC:18707

NCBI Gene ID: 160622

neXtProt AC: NX_Q7Z6J2

UniProt: Q7Z6J2
Chr Location

12q13.13; chr12:52006946-52015889 (+) GRCh38

MGI Vertebrate Homology

Tamalin stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TAMALIN
Gene Tree

Tamalin

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Tamalin
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available

Mice homozygous for targeted null mutations develop and behave normally under ordinary conditions but display a marked reduction in sensitivity to acute morphine responses and impaired adaptive responses to morphine and cocaine.

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All GO Annotations

24
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

9
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tamalin

ZFIN tamalin

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All Sequences

32
RefSeq

4
UniProt

1
CCDS

CCDS27847.1

Ensembl

ENSMUSG00000000531 (Evidence)
NCBI Gene

56149

			Length	Strain/Species	Flank
genomic	56149	NCBI Gene Model \| MGI Sequence Detail	8550	C57BL/6J	± kb
transcript	NM_019518	RefSeq \| MGI Sequence Detail	2025	Not Specified
polypeptide	Q9JJA9	UniProt \| EBI \| MGI Sequence Detail	392	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008221 protein TAMALIN

(term hierarchy)
InterPro Domains

IPR052122 Intracellular Trafficking and Signaling Regulator

IPR001478 PDZ domain

IPR036034 PDZ superfamily

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 3

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MGI:6456883

Summaries

All 54

Developmental Gene Expression 2

Diseases 1

Gene Ontology 7

Phenotypes 30
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:336849 Martinez-Garcia M, et al., GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans. PLoS Genet. 2023 Feb;19(2):e1010666

TSS for Tamalin:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133196	Chr15:101122098-101122112 (+)	17 bp
Tssr133197	Chr15:101122203-101122219 (+)	123 bp
Tssr4725	Chr15:101126200-101126225 (+)	4,125 bp
Tssr133198	Chr15:101130085-101130089 (+)	7,999 bp
Tssr133199	Chr15:101130284-101130314 (+)	8,211 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24