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Rabggta Gene Detail
Summary
  • Symbol
    Rabggta
  • Name
    Rab geranylgeranyl transferase, a subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860443
    NCBI Gene: 56187
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55953321-55959720 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860443
 protein coding gene Chr14:55952873-55959720 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021365
 protein coding gene Chr14:49758360-49764744 (-)
A/J MGP_AJ_G0021324
 protein coding gene Chr14:48769693-48776076 (-)
AKR/J MGP_AKRJ_G0021300
 protein coding gene Chr14:50520305-50526689 (-)
BALB/cJ MGP_BALBcJ_G0021328
 protein coding gene Chr14:48735396-48741780 (-)
C3H/HeJ MGP_C3HHeJ_G0021108
 protein coding gene Chr14:50201661-50208045 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021766
 protein coding gene Chr14:52251749-52258133 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019313
 protein coding gene Chr14:47138978-47145479 (-)
CAST/EiJ MGP_CASTEiJ_G0020627
 protein coding gene Chr14:46465249-46471626 (-)
CBA/J MGP_CBAJ_G0021075
 protein coding gene Chr14:53819283-53825667 (-)
DBA/2J MGP_DBA2J_G0021196
 protein coding gene Chr14:48489014-48495398 (-)
FVB/NJ MGP_FVBNJ_G0021178
 protein coding gene Chr14:47936717-47943072 (-)
LP/J MGP_LPJ_G0021270
 protein coding gene Chr14:50806664-50813048 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021202
 protein coding gene Chr14:53172880-53179264 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021793
 protein coding gene Chr14:49701656-49708040 (-)
PWK/PhJ MGP_PWKPhJ_G0020374
 protein coding gene Chr14:45022562-45029112 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020202
 protein coding gene Chr14:45707156-45713576 (-)
WSB/EiJ MGP_WSBEiJ_G0020680
 protein coding gene Chr14:49985971-49992355 (-)



Homology
more
  • Human Ortholog
    RABGGTA, Rab geranylgeranyltransferase subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RABGGTA, Rab geranylgeranyltransferase subunit alpha
  • Synonyms
    PTAR3
  • Links
    NCBI Gene ID: 5875
    neXtProt AC: NX_Q92696
    UniProt: Q92696

  • Chr Location
    14q12; chr14:24265538-24271627 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rabggta mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes exhibit diluted pigmentation, a platelet defect resulting in prolonged bleeding, macrothrombocytopenia, impaired killing by cytotoxic T lymphocytes, high mortality, and poor breeding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56187 NCBI Gene Model | MGI Sequence Detail 6400 C57BL/6J ±  kb
    transcript NR_153435 RefSeq | MGI Sequence Detail 2540 ZRU/MplStud  
    polypeptide Q9JHK4 UniProt | EBI | MGI Sequence Detail 567 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013653 geranylgeranyl transferase type-2 subunit alpha
      (term hierarchy)
    • EC
      2.5.1.60
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR002088 Protein prenyltransferase, alpha subunit
      IPR009087 Rab geranylgeranyltransferase, alpha subunit, insert-domain
      IPR036254 Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 6
      cDNA 51

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10168, MGI:95761
    References
    more
    • Summaries
      All 58
      Diseases 2
      Gene Ontology 7
      Phenotypes 28
    • Earliest
      J:12434 Swank RT, et al., Inherited abnormalities in platelet organelles and platelet formation and associated altered expression of low molecular weight guanosine triphosphate-binding proteins in the mouse pigment mutant gunmetal. Blood. 1993 May 15;81(10):2626-35
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory