Phc2 MGI Mouse Gene Detail - MGI:1860454

Symbol

Phc2
Name

polyhomeotic 2
Synonyms

D130050K19Rik, D4Ertd810e, Edr2, Mph2

Feature Type

protein coding gene
IDs

MGI:1860454
NCBI Gene: 54383
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr4:128548495-128646674 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 62.12 cM
Mapping Data

4 experiments

SNPs within 2kb

1188 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860454	protein coding gene	Chr4:128548448-128646674 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028805	protein coding gene	Chr4:130474306-130577585 (+)
A/J	MGP_AJ_G0028764	protein coding gene	Chr4:125321340-125421274 (+)
AKR/J	MGP_AKRJ_G0028717	protein coding gene	Chr4:128784379-128887194 (+)
BALB/cJ	MGP_BALBcJ_G0028787	protein coding gene	Chr4:125898105-125996787 (+)
C3H/HeJ	MGP_C3HHeJ_G0028501	protein coding gene	Chr4:128840486-128946525 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029229	protein coding gene	Chr4:135422898-135537306 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026502	protein coding gene	Chr4:118452237-118549570 (+)
CAST/EiJ	MGP_CASTEiJ_G0027934	protein coding gene	Chr4:127005130-127103759 (+)
CBA/J	MGP_CBAJ_G0028467	protein coding gene	Chr4:138717614-138827382 (+)
DBA/2J	MGP_DBA2J_G0028616	protein coding gene	Chr4:125750970-125849291 (+)
FVB/NJ	MGP_FVBNJ_G0028583	protein coding gene	Chr4:124501201-124600953 (+)
LP/J	MGP_LPJ_G0028717	protein coding gene	Chr4:130790152-130895948 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028609	protein coding gene	Chr4:143649751-143753869 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029267	protein coding gene	Chr4:129155705-129257268 (+)
PWK/PhJ	MGP_PWKPhJ_G0027655	protein coding gene	Chr4:122312606-122412949 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027482	protein coding gene	Chr4:125003037-125106417 (+)
WSB/EiJ	MGP_WSBEiJ_G0028014	protein coding gene	Chr4:129259188-129364793 (+)

Human Ortholog

PHC2, polyhomeotic homolog 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PHC2, polyhomeotic homolog 2
Synonyms

EDR2, HPH2, PH2
Links

HGNC:3183

NCBI Gene ID: 1912

neXtProt AC: NX_Q8IXK0

UniProt: Q8IXK0
Chr Location

1p35.1; chr1:33323623-33431095 (-) GRCh38

MGI Vertebrate Homology

Phc2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PHC2
Gene Tree

Phc2

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Phenotype Summary

18 phenotypes from 5 alleles in 2 genetic backgrounds
29 phenotypes from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

45
Chemically induced (other)

2
Gene trapped

34
Radiation induced

1
Targeted

8
Genomic Mutations

4 involving Phc2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

83 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele have normal skulls but exhibit posterior homeotic transformations of the axial skeleton. Cultured mouse embryonic fibroblasts show defects in proliferation and premature senescence.

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All GO Annotations

28
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

794
Tissues

52
cDNA Data

10
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase phc2

ZFIN phc2a

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All Sequences

89
RefSeq

20
UniProt

7
CCDS

CCDS18674.1, CCDS57297.1

Ensembl

ENSMUSG00000028796 (Evidence)
NCBI Gene

54383

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028796	Ensembl Gene Model \| MGI Sequence Detail	98180	C57BL/6J	± kb
transcript	ENSMUST00000106080	Ensembl \| MGI Sequence Detail	3885	Not Applicable
polypeptide	ENSMUSP00000101690	Ensembl \| MGI Sequence Detail	850	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000012634 polyhomeotic-like protein 2

(term hierarchy)
PDB

2NA1
InterPro Domains

IPR038603 FCS-type zinc finger superfamily

IPR050548 Polycomb group and chromatin remodeling factors

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR012313 Zinc finger, FCS-type

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All nucleic 14

cDNA 12

Primer pair 2

Microarray probesets 3

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MGI:1289316, MGI:2140153, MGI:2441942

Summaries

All 66

Developmental Gene Expression 11

Gene Ontology 18

Phenotypes 18
Earliest

J:62648 Hemenway CS, et al., The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains. Oncogene. 1998 May 14;16(19):2541-7
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Phc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39068	Chr4:128548479-128548522 (+)	6 bp
Tssr39069	Chr4:128582519-128582543 (+)	34,036 bp
Tssr39070	Chr4:128605636-128605672 (+)	57,159 bp
Tssr39071	Chr4:128615974-128615984 (+)	67,484 bp
Tssr39072	Chr4:128621361-128621372 (+)	72,872 bp
Tssr39073	Chr4:128621382-128621437 (+)	72,915 bp
Tssr39074	Chr4:128637226-128637245 (+)	88,741 bp
Tssr39075	Chr4:128638783-128638802 (+)	90,298 bp
Tssr39076	Chr4:128638842-128638860 (+)	90,356 bp
Tssr39077	Chr4:128640917-128640937 (+)	92,432 bp
Tssr39078	Chr4:128645847-128645884 (+)	97,371 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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