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Proz Gene Detail
Summary
  • Symbol
    Proz
  • Name
    protein Z, vitamin K-dependent plasma glycoprotein
  • Synonyms
    1300015B06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860488
    NCBI Gene: 66901
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:13110914-13126026 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.73 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    592 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860488
 protein coding gene Chr8:13110583-13126026 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033370
 protein coding gene Chr8:10374433-10389727 (+)
A/J MGP_AJ_G0033350
 protein coding gene Chr8:10006338-10018672 (+)
AKR/J MGP_AKRJ_G0033281
 protein coding gene Chr8:10271854-10287149 (+)
BALB/cJ MGP_BALBcJ_G0033351
 protein coding gene Chr8:10146425-10160356 (+)
C3H/HeJ MGP_C3HHeJ_G0033064
 protein coding gene Chr8:10483519-10496055 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033863
 protein coding gene Chr8:10740380-10757988 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030832
 protein coding gene Chr8:9517333-9527199 (+)
CAST/EiJ MGP_CASTEiJ_G0032386
 protein coding gene Chr8:10245279-10257667 (+)
CBA/J MGP_CBAJ_G0033037
 protein coding gene Chr8:11193921-11206648 (+)
DBA/2J MGP_DBA2J_G0033190
 protein coding gene Chr8:9965164-9977654 (+)
FVB/NJ MGP_FVBNJ_G0033139
 protein coding gene Chr8:9970114-9983362 (+)
LP/J MGP_LPJ_G0033284
 protein coding gene Chr8:10297859-10311754 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033173
 protein coding gene Chr8:11447947-11461518 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033880
 protein coding gene Chr8:10335839-10355106 (+)
PWK/PhJ MGP_PWKPhJ_G0032099
 protein coding gene Chr8:10010559-10023359 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031941
 protein coding gene Chr8:10225580-10242700 (+)
WSB/EiJ MGP_WSBEiJ_G0032502
 protein coding gene Chr8:10370664-10384506 (+)



Homology
more
  • Human Ortholog
    PROZ, protein Z, vitamin K dependent plasma glycoprotein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PROZ, protein Z, vitamin K dependent plasma glycoprotein
  • Synonyms
    PZ
  • Links
    NCBI Gene ID: 8858
    neXtProt AC: NX_P22891
    UniProt: P22891

  • Chr Location
    13q34; chr13:113158648-113172386 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PROZ associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
When unchallenged, mice homozygous for a knock-out allele do not express an obvious phenotype; however, homozygotes exhibit significantly reduced survival following collagen/epinephrine-induced thromboembolism and develop enhanced thrombosis in the ferric chloride-induced arterial injury model.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    2
  • cDNA Data
    16
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031445 Ensembl Gene Model | MGI Sequence Detail 15113 C57BL/6J ±  kb
transcript ENSMUST00000033822 Ensembl | MGI Sequence Detail 3361 Not Applicable  
polypeptide ENSMUSP00000033822 Ensembl | MGI Sequence Detail 399 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013275 vitamin K-dependent protein Z
    (term hierarchy)
  • InterPro Domains
    IPR017857 Coagulation factor-like, Gla domain superfamily
    IPR001881 EGF-like calcium-binding domain
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
    IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
    IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
    IPR050442 Peptidase S1 family, coagulation factors
    IPR009003 Peptidase S1, PA clan
    IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
    IPR001254 Serine proteases, trypsin domain
  • GlyGen
    Q9CQW3 4 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 18
    cDNA 16
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914151
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:62716 Yin ZF, et al., Prothrombotic phenotype of protein Z deficiency. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6734-8
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory