Arhgef7 MGI Mouse Gene Detail - MGI:1860493 - Rho guanine nucleotide exchange factor

Symbol

Arhgef7
Name

Rho guanine nucleotide exchange factor
Synonyms

betaPix, betaPix-b, betaPix-c, Cool, cool-1, p85SPR, Pak interacting exchange factor, PIX

Feature Type

protein coding gene
IDs

MGI:1860493
NCBI Gene: 54126
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr8:11778053-11885219 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 5.73 cM
Mapping Data

1 experiment

SNPs within 2kb

2629 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860493	protein coding gene	Chr8:11777721-11885219 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033359	protein coding gene	Chr8:8975675-9089307 (+)
A/J	MGP_AJ_G0033339	protein coding gene	Chr8:8657051-8770334 (+)
AKR/J	MGP_AKRJ_G0033270	protein coding gene	Chr8:8911920-9021760 (+)
BALB/cJ	MGP_BALBcJ_G0033340	protein coding gene	Chr8:8795097-8902812 (+)
C3H/HeJ	MGP_C3HHeJ_G0033053	protein coding gene	Chr8:9081696-9194757 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033852	protein coding gene	Chr8:9326220-9439315 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030821	protein coding gene	Chr8:8178899-8298793 (+)
CAST/EiJ	MGP_CASTEiJ_G0032375	protein coding gene	Chr8:8830560-8937993 (+)
CBA/J	MGP_CBAJ_G0033026	protein coding gene	Chr8:9726758-9840681 (+)
DBA/2J	MGP_DBA2J_G0033179	protein coding gene	Chr8:8632405-8739504 (+)
FVB/NJ	MGP_FVBNJ_G0033128	protein coding gene	Chr8:8599227-8712703 (+)
LP/J	MGP_LPJ_G0033273	protein coding gene	Chr8:8896813-9010858 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033162	protein coding gene	Chr8:10017851-10129864 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033869	protein coding gene	Chr8:8926729-9040991 (+)
PWK/PhJ	MGP_PWKPhJ_G0032088	protein coding gene	Chr8:8637776-8745129 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031930	protein coding gene	Chr8:8835373-8945406 (+)
WSB/EiJ	MGP_WSBEiJ_G0032491	protein coding gene	Chr8:8967162-9081346 (+)

Human Ortholog

ARHGEF7, Rho guanine nucleotide exchange factor 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGEF7, Rho guanine nucleotide exchange factor 7
Synonyms

BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
Links

HGNC:15607

NCBI Gene ID: 8874

neXtProt AC: NX_Q14155

UniProt: Q14155
Chr Location

13q34; chr13:111114559-111305737 (+) GRCh38

MGI Vertebrate Homology

Arhgef7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARHGEF7
Gene Tree

Arhgef7

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Phenotype Summary

17 phenotypes from 4 alleles in 4 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

1
Gene trapped

8
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit placental defects and complete lethality throughout fetal growth and development. Mice homozygous for a different null allele exhibit embryonic death around E8.5, double axis, and impaired anterior visceral endoderm cell migration.

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All GO Annotations

62
GO References

21

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

46
cDNA Data

175
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ARHGEF7

Xenbase arhgef7

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All Sequences

108
RefSeq

40
UniProt

7
CCDS

CCDS22099.1, CCDS52480.1, CCDS52481.1

Ensembl

ENSMUSG00000031511 (Evidence)
NCBI Gene

54126

			Length	Strain/Species	Flank
genomic	54126	NCBI Gene Model \| MGI Sequence Detail	107167	C57BL/6J	± kb
transcript	NM_001113517	RefSeq \| MGI Sequence Detail	4973	C57BL/6
polypeptide	Q9ES28	UniProt \| EBI \| MGI Sequence Detail	862	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000004260 Rho guanine nucleotide exchange factor 7

(term hierarchy)
PDB

2ESW, 6JMT
InterPro Domains

IPR001715 Calponin homology domain

IPR036872 CH domain superfamily

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR046376 RhoGEF 6/7, PH domain

IPR032409 Rho guanine nucleotide exchange factor 6/7, coiled-coil domain

IPR035789 Rho guanine nucleotide exchange factor 7, SH3 domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q9ES28 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)

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All nucleic 178

Genomic 1

cDNA 176

Primer pair 1

Microarray probesets 5

Summaries

All 80

Developmental Gene Expression 10

Gene Ontology 21

Phenotypes 21
Earliest

J:63104 Oh WK, et al., Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. Biochem Biophys Res Commun. 1997 Jun 27;235(3):794-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arhgef7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76234	Chr8:11777817-11777831 (+)	-229 bp
Tssr76235	Chr8:11777945-11777967 (+)	-97 bp
Tssr76236	Chr8:11778012-11778037 (+)	-28 bp
Tssr76237	Chr8:11778040-11778068 (+)	1 bp
Tssr76238	Chr8:11778070-11778095 (+)	30 bp
Tssr76239	Chr8:11778105-11778143 (+)	71 bp
Tssr76240	Chr8:11778169-11778256 (+)	160 bp
Tssr76241	Chr8:11806185-11806189 (+)	28,134 bp
Tssr76242	Chr8:11808329-11808375 (+)	30,299 bp
Tssr76243	Chr8:11808380-11808412 (+)	30,343 bp
Tssr76244	Chr8:11829213-11829224 (+)	51,166 bp
Tssr76245	Chr8:11829275-11829294 (+)	51,232 bp
Tssr76246	Chr8:11832453-11832481 (+)	54,414 bp
Tssr76247	Chr8:11847374-11847387 (+)	69,328 bp
Tssr76248	Chr8:11847411-11847448 (+)	69,377 bp
Tssr76249	Chr8:11848720-11848730 (+)	70,672 bp
Tssr76250	Chr8:11860325-11860350 (+)	82,285 bp
Tssr76251	Chr8:11862381-11862385 (+)	84,330 bp
Tssr76252	Chr8:11872306-11872310 (+)	94,255 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24