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Adam21 Gene Detail
Summary
  • Symbol
    Adam21
  • Name
    a disintegrin and metallopeptidase domain 21
  • Synonyms
    ADAM31
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861229
    NCBI Gene: 56622
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:81605358-81615248 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 37.79 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    214 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861229
 protein coding gene Chr12:81605349-81615248 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019904
 protein coding gene Chr12:82030910-82040803 (-)
A/J MGP_AJ_G0019861
 protein coding gene Chr12:79034491-79043053 (-)
AKR/J MGP_AKRJ_G0019837
 protein coding gene Chr12:81179169-81189760 (-)
BALB/cJ MGP_BALBcJ_G0019841
 protein coding gene Chr12:79258934-79267718 (-)
C3H/HeJ MGP_C3HHeJ_G0019647
 protein coding gene Chr12:81642394-81652334 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020293
 protein coding gene Chr12:84417612-84425778 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017910
 protein coding gene Chr12:76000565-76010434 (-)
CAST/EiJ MGP_CASTEiJ_G0019196
 protein coding gene Chr12:76529174-76539895 (-)
CBA/J MGP_CBAJ_G0019618
 protein coding gene Chr12:87686992-87696618 (-)
DBA/2J MGP_DBA2J_G0019733
 protein coding gene Chr12:78612323-78621240 (-)
FVB/NJ MGP_FVBNJ_G0019719
 protein coding gene Chr12:77459038-77468794 (-)
LP/J MGP_LPJ_G0019805
 protein coding gene Chr12:81934677-81948848 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019758
 protein coding gene Chr12:90696963-90705939 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020327
 protein coding gene Chr12:80708890-80717648 (-)
PWK/PhJ MGP_PWKPhJ_G0018961
 protein coding gene Chr12:73018740-73029841 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018755
 protein coding gene Chr12:75229013-75239180 (-)
WSB/EiJ MGP_WSBEiJ_G0019248
 protein coding gene Chr12:81354578-81366229 (-)



Homology
more
  • Human Ortholog
    ADAM21, ADAM metallopeptidase domain 21
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM21, ADAM metallopeptidase domain 21
  • Synonyms
    ADAM 21, ADAM31
  • Links
    NCBI Gene ID: 8747
    neXtProt AC: NX_Q9UKJ8
    UniProt: Q9UKJ8

  • Chr Location
    14q24.2; chr14:70417107-70460427 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    45
  • cDNA Data
    8
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000008438 Ensembl Gene Model | MGI Sequence Detail 9891 C57BL/6J ±  kb
transcript ENSMUST00000008582 Ensembl | MGI Sequence Detail 2911 Not Applicable  
polypeptide ENSMUSP00000008582 Ensembl | MGI Sequence Detail 729 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:56486 Seldin MF, et al., Chromosomal mapping of Adam9, Adam15 and Adam21. Matrix Biol. 2000 May;19(2):185-7
  • Latest
    J:324150 Chen Y, et al., Adam21 is dispensable for reproductive processes in mice. PeerJ. 2021;9:e12210
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory