Fntb MGI Mouse Gene Detail - MGI:1861305 - farnesyltransferase, CAAX box, beta

Symbol

Fntb
Name

farnesyltransferase, CAAX box, beta
Synonyms

2010013E13Rik

Feature Type

protein coding gene
IDs

MGI:1861305
NCBI Gene: 110606
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr12:76884014-76968188 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 33.73 cM
Mapping Data

3 experiments

SNPs within 2kb

2496 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1861305	protein coding gene	Chr12:76812363-76968188 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019864	protein coding gene	Chr12:76889810-77063573 (+)
A/J	MGP_AJ_G0019821	protein coding gene	Chr12:73960978-74125067 (+)
AKR/J	MGP_AKRJ_G0019797	protein coding gene	Chr12:76202168-76379545 (+)
BALB/cJ	MGP_BALBcJ_G0019800	protein coding gene	Chr12:74428875-74593663 (+)
C3H/HeJ	MGP_C3HHeJ_G0019606	protein coding gene	Chr12:76668576-76837788 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020253	protein coding gene	Chr12:79245358-79409172 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017871	protein coding gene	Chr12:71295759-71457796 (+)
CAST/EiJ	MGP_CASTEiJ_G0019158	protein coding gene	Chr12:71480420-71648518 (+)
CBA/J	MGP_CBAJ_G0019577	protein coding gene	Chr12:82311339-82493297 (+)
DBA/2J	MGP_DBA2J_G0019693	protein coding gene	Chr12:73833814-73991784 (+)
FVB/NJ	MGP_FVBNJ_G0019679	protein coding gene	Chr12:72656554-72822573 (+)
LP/J	MGP_LPJ_G0019765	protein coding gene	Chr12:76861346-77040803 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019719	protein coding gene	Chr12:85312592-85478512 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020289	protein coding gene	Chr12:75691875-75855328 (+)
PWK/PhJ	MGP_PWKPhJ_G0018924	protein coding gene	Chr12:68174500-68344838 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018718	protein coding gene	Chr12:70192075-70350937 (+)
WSB/EiJ	MGP_WSBEiJ_G0019209	protein coding gene	Chr12:76297425-76466467 (+)

Human Ortholog

CHURC1-FNTB, CHURC1-FNTB readthrough

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHURC1-FNTB, CHURC1-FNTB readthrough
Synonyms

FNTB, FTase-beta
Links

HGNC:42960

NCBI Gene ID: 100529261

neXtProt AC: NX_P49356
Chr Location

14q23.3; chr14:64914361-65062655 (+) GRCh38

Human Ortholog

FNTB, farnesyltransferase, CAAX box, subunit beta
Synonyms

FPTB
Links

HGNC:3785

NCBI Gene ID: 2342

neXtProt AC: NX_P49356

UniProt: P49356
Chr Location

14q23.3; chr14:64986895-65062652 (+) GRCh38

MGI Vertebrate Homology

Fntb stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CHURC1-FNTB, FNTB
Gene Tree

Fntb

Diseases

1 with human FNTB associations

				Human Disease	Mouse Models
				anxiety disorder IDs anxiety disorder DOID:2030 DOID:12884 ICD10CM:F41.9 ICD9CM:300.09 MESH:D001008 NCI:C2878 OMIM:607834 UMLS_CUI:C0003469

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 5 alleles in 6 genetic backgrounds
13 phenotypes from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

215
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

205
Targeted

7
Genomic Mutations

1 involving Fntb
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

208 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit early embryonic lethality and loss epiblast-derived structures as a result of decreased cell proliferation and increased apoptosis. Cultured blastocysts corresponding to E7.5 embryos display a dramatic decrease in inner cell mass proliferation.

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All GO Annotations

27
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

67
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fntb

ZFIN fntb

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All Sequences

55
RefSeq

7
UniProt

3
CCDS

CCDS25998.1

Ensembl

ENSMUSG00000033373 (Evidence)
NCBI Gene

110606

			Length	Strain/Species	Flank
genomic	110606	NCBI Gene Model \| MGI Sequence Detail	84175	C57BL/6J	± kb
transcript	NM_145927	RefSeq \| MGI Sequence Detail	2613	ZRU/MplStud
polypeptide	Q8K2I1	UniProt \| EBI \| MGI Sequence Detail	437	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007592 protein farnesyltransferase subunit beta

(term hierarchy)
PDB

3PZ4
EC

2.5.1.58
InterPro Domains

IPR038543 Churchill superfamily

IPR001330 PFTB repeat

IPR045089 Prenyltransferase subunit beta

IPR026872 Protein farnesyltransferase subunit beta

IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

IPR009508 Transcription activator, Churchill

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All nucleic 67

cDNA 67

Microarray probesets 3

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MGI:1917513, MGI:2144730

Summaries

All 52

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 26
Earliest

J:56486 Seldin MF, et al., Chromosomal mapping of Adam9, Adam15 and Adam21. Matrix Biol. 2000 May;19(2):185-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fntb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113991	Chr12:76884182-76884240 (+)	197 bp
Tssr113992	Chr12:76884243-76884254 (+)	235 bp
Tssr113993	Chr12:76933819-76933857 (+)	49,824 bp
Tssr113994	Chr12:76943587-76943588 (+)	59,574 bp
Tssr113995	Chr12:76948918-76948929 (+)	64,910 bp
Tssr113996	Chr12:76948944-76948956 (+)	64,936 bp
Tssr113997	Chr12:76948961-76948975 (+)	64,954 bp
Tssr113998	Chr12:76948981-76949005 (+)	64,979 bp
Tssr113999	Chr12:76956216-76956230 (+)	72,209 bp
Tssr114000	Chr12:76956257-76956270 (+)	72,250 bp
Tssr114001	Chr12:76956275-76956285 (+)	72,266 bp
Tssr3867	Chr12:76956288-76956293 (+)	72,277 bp
Tssr114002	Chr12:76961410-76961429 (+)	77,406 bp
Tssr114003	Chr12:76963191-76963216 (+)	79,190 bp
Tssr114004	Chr12:76967518-76967531 (+)	83,511 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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