Sphk2 MGI Mouse Gene Detail - MGI:1861380

Symbol

Sphk2
Name

sphingosine kinase 2

Feature Type

protein coding gene
IDs

MGI:1861380
NCBI Gene: 56632
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr7:45358891-45367426 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.45 cM
Mapping Data

2 experiments

SNPs within 2kb

261 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1861380	protein coding gene	Chr7:45358887-45367426 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032242	protein coding gene	Chr7:46018028-46026535 (-)
A/J	MGP_AJ_G0032221	protein coding gene	Chr7:45105437-45113972 (-)
AKR/J	MGP_AKRJ_G0032157	protein coding gene	Chr7:46357534-46366072 (-)
BALB/cJ	MGP_BALBcJ_G0032233	protein coding gene	Chr7:45100185-45108721 (-)
C3H/HeJ	MGP_C3HHeJ_G0031948	protein coding gene	Chr7:46851789-46860325 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032725	protein coding gene	Chr7:48268646-48277189 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029739	protein coding gene	Chr7:47659506-47667971 (-)
CAST/EiJ	MGP_CASTEiJ_G0031277	protein coding gene	Chr7:38292052-38300591 (-)
CBA/J	MGP_CBAJ_G0031913	protein coding gene	Chr7:49878401-49886981 (-)
DBA/2J	MGP_DBA2J_G0032071	protein coding gene	Chr7:44786059-44794571 (-)
FVB/NJ	MGP_FVBNJ_G0032022	protein coding gene	Chr7:44558747-44567291 (-)
LP/J	MGP_LPJ_G0032149	protein coding gene	Chr7:46722693-46731226 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032059	protein coding gene	Chr7:48559371-48567961 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032741	protein coding gene	Chr7:45568762-45577298 (-)
PWK/PhJ	MGP_PWKPhJ_G0030999	protein coding gene	Chr7:38152976-38161519 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030837	protein coding gene	Chr7:33599542-33609549 (-)
WSB/EiJ	MGP_WSBEiJ_G0031394	protein coding gene	Chr7:46073045-46081581 (-)

Human Ortholog

SPHK2, sphingosine kinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPHK2, sphingosine kinase 2
Synonyms

SK 2, SK-2, SPK 2, SPK-2
Links

HGNC:18859

NCBI Gene ID: 56848

neXtProt AC: NX_Q9NRA0

UniProt: Q9NRA0
Chr Location

19q13.33; chr19:48619291-48630717 (+) GRCh38

MGI Vertebrate Homology

Sphk2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SPHK2
Gene Tree

Sphk2

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Phenotype Summary

6 phenotypes from 4 alleles in 4 genetic backgrounds
35 phenotypes from multigenic genotypes
2 images
101 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

4
Gene trapped

16
Targeted

10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available

Mice homozygous for a disruption in this gene display a normal phenotype.

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All GO Annotations

72
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

873
Tissues

165
cDNA Data

15
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sphk2

ZFIN sphk2

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All Sequences

68
RefSeq

12
UniProt

4
CCDS

CCDS21261.1

Ensembl

ENSMUSG00000057342 (Evidence)
NCBI Gene

56632

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057342	Ensembl Gene Model \| MGI Sequence Detail	8536	C57BL/6J	± kb
transcript	ENSMUST00000107737	Ensembl \| MGI Sequence Detail	3548	Not Applicable
polypeptide	ENSMUSP00000103366	Ensembl \| MGI Sequence Detail	617	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015523 sphingosine kinase 2

(term hierarchy)
EC

2.7.1.91
InterPro Domains

IPR001206 Diacylglycerol kinase, catalytic domain

IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal

IPR050187 Lipid Phosphate Formation and Regulation

IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily

IPR045540 YegS/DAGK, C-terminal domain

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All nucleic 20

cDNA 16

Primer pair 4

Microarray probesets 4

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MGI:2142309

Summaries

All 161

Developmental Gene Expression 13

Gene Ontology 16

Phenotypes 101
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:352028 Green CD, et al., Sphingosine kinase 2 and p62 regulation are determinants of sexual dimorphism in hepatocellular carcinoma. Mol Metab. 2024 Aug;86:101971

TSS for Sphk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr72461	Chr7:45367382-45367398 (-)	36 bp
Tssr72460	Chr7:45367343-45367374 (-)	67 bp
Tssr72459	Chr7:45367314-45367342 (-)	98 bp
Tssr72458	Chr7:45367043-45367100 (-)	354 bp
Tssr72457	Chr7:45366765-45366777 (-)	655 bp
Tssr72456	Chr7:45366491-45366517 (-)	922 bp
Tssr72455	Chr7:45366462-45366469 (-)	960 bp
Tssr72454	Chr7:45366455-45366458 (-)	969 bp
Tssr72453	Chr7:45364604-45364636 (-)	2,806 bp
Tssr72452	Chr7:45364122-45364153 (-)	3,288 bp
Tssr72451	Chr7:45364104-45364120 (-)	3,314 bp
Tssr72450	Chr7:45364091-45364102 (-)	3,329 bp
Tssr72449	Chr7:45362987-45363013 (-)	4,426 bp
Tssr72448	Chr7:45361876-45361893 (-)	5,541 bp
Tssr72447	Chr7:45361731-45361747 (-)	5,687 bp
Tssr72446	Chr7:45360961-45360990 (-)	6,450 bp
Tssr72445	Chr7:45360868-45360911 (-)	6,536 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24