Ctsf MGI Mouse Gene Detail - MGI:1861434

Symbol

Ctsf
Name

cathepsin F

Feature Type

protein coding gene
IDs

MGI:1861434
NCBI Gene: 56464
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:4905158-4910946 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.12 cM
Mapping Data

3 experiments

SNPs within 2kb

261 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1861434	protein coding gene	Chr19:4905153-4910946 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024677	protein coding gene	Chr19:1756445-1762228 (+)
A/J	MGP_AJ_G0024643	protein coding gene	Chr19:1674575-1680358 (+)
AKR/J	MGP_AKRJ_G0024616	protein coding gene	Chr19:1721077-1726860 (+)
BALB/cJ	MGP_BALBcJ_G0024643	protein coding gene	Chr19:1667025-1672808 (+)
C3H/HeJ	MGP_C3HHeJ_G0024411	protein coding gene	Chr19:1721938-1727721 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025090	protein coding gene	Chr19:1810833-1816616 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022520	protein coding gene	Chr19:1605134-1610964 (+)
CAST/EiJ	MGP_CASTEiJ_G0023883	protein coding gene	Chr19:1744992-1750782 (+)
CBA/J	MGP_CBAJ_G0024382	protein coding gene	Chr19:1887436-1893219 (+)
DBA/2J	MGP_DBA2J_G0024510	protein coding gene	Chr19:1640583-1646366 (+)
FVB/NJ	MGP_FVBNJ_G0024477	protein coding gene	Chr19:1662201-1667978 (+)
LP/J	MGP_LPJ_G0024596	protein coding gene	Chr19:1765821-1771604 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024507	protein coding gene	Chr19:1790153-1795936 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025138	protein coding gene	Chr19:1712352-1718135 (+)
PWK/PhJ	MGP_PWKPhJ_G0023629	protein coding gene	Chr19:1688984-1694755 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023434	protein coding gene	Chr19:1705265-1711050 (+)
WSB/EiJ	MGP_WSBEiJ_G0023945	protein coding gene	Chr19:1713065-1718848 (+)

Human Ortholog

CTSF, cathepsin F

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTSF, cathepsin F
Synonyms

CATSF, CLN13
Links

HGNC:2531

NCBI Gene ID: 8722

neXtProt AC: NX_Q9UBX1

UniProt: Q9UBX1
Chr Location

11q13.2; chr11:66563464-66568879 (-) GRCh38

MGI Vertebrate Homology

Ctsf stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CTSF
Gene Tree

Ctsf

Diseases

1 with human CTSF associations

				Human Disease	Mouse Models
				neuronal ceroid lipofuscinosis 13 IDs neuronal ceroid lipofuscinosis 13 DOID:0110727 ICD10CM:E75.4 OMIM:615362 ORDO:352709

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Gene trapped

8
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele develop neuronal lipofuscinosis and late-onset neurological disease characterized by reduced brain mass, progressive hind leg weakness, impaired motor coordination, tremors, severe gliosis, general wasting, and premature death.

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

2
cDNA Data

65
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctsf

ZFIN ctsf

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All Sequences

63
RefSeq

4
UniProt

6
CCDS

CCDS29440.1

Ensembl

ENSMUSG00000083282 (Evidence)
NCBI Gene

56464

			Length	Strain/Species	Flank
genomic	ENSMUSG00000083282	Ensembl Gene Model \| MGI Sequence Detail	5789	C57BL/6J	± kb
transcript	ENSMUST00000119694	Ensembl \| MGI Sequence Detail	1980	Not Applicable
polypeptide	ENSMUSP00000112481	Ensembl \| MGI Sequence Detail	462	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006027 cathepsin F

(term hierarchy)
EC

3.4.22.41
InterPro Domains

IPR013201 Cathepsin propeptide inhibitor domain (I29)

IPR000169 Cysteine peptidase, cysteine active site

IPR025660 Cysteine peptidase, histidine active site

IPR039417 Papain-like cysteine endopeptidase

IPR038765 Papain-like cysteine peptidase superfamily

IPR013128 Peptidase C1A

IPR000668 Peptidase C1A, papain C-terminal
GlyGen

Q9R013 6 sites, 9 N-linked glycans (5 sites)

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All nucleic 65

cDNA 65

Microarray probesets 4

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MGI:2147567

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 7
Earliest

J:58089 Tisljar K, et al., Cathepsin J, a novel murine cysteine protease of the papain family with a placenta-restricted expression. FEBS Lett. 1999 Oct 15;459(3):299-304
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Ctsf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154363	Chr19:4905175-4905297 (+)	78 bp
Tssr154364	Chr19:4909250-4909290 (+)	4,112 bp
Tssr154365	Chr19:4909401-4909414 (+)	4,250 bp
Tssr154366	Chr19:4909437-4909450 (+)	4,286 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24