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Gcm2 Gene Detail
Summary
  • Symbol
    Gcm2
  • Name
    glial cells missing homolog 2
  • Synonyms
    Gcm1-rs2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861438
    NCBI Gene: 107889
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr13:41254903-41264511 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 20.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    473 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861438
 protein coding gene Chr13:41254903-41264511 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020484
 protein coding gene Chr13:39582306-39590847 (-)
A/J MGP_AJ_G0020438
 protein coding gene Chr13:38260692-38269245 (-)
AKR/J MGP_AKRJ_G0020416
 protein coding gene Chr13:39299926-39309792 (-)
BALB/cJ MGP_BALBcJ_G0020434
 protein coding gene Chr13:38445978-38454533 (-)
C3H/HeJ MGP_C3HHeJ_G0020233
 protein coding gene Chr13:39182753-39191304 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020867
 protein coding gene Chr13:40837751-40846312 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018454
 protein coding gene Chr13:36393728-36402452 (-)
CAST/EiJ MGP_CASTEiJ_G0019748
 protein coding gene Chr13:38956439-38965058 (-)
CBA/J MGP_CBAJ_G0020194
 protein coding gene Chr13:42590863-42599365 (-)
DBA/2J MGP_DBA2J_G0020316
 protein coding gene Chr13:37833002-37841517 (-)
FVB/NJ MGP_FVBNJ_G0020295
 protein coding gene Chr13:37329157-37337710 (-)
LP/J MGP_LPJ_G0020391
 protein coding gene Chr13:39822179-39830923 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020324
 protein coding gene Chr13:42555046-42563610 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020910
 protein coding gene Chr13:38952549-38961108 (-)
PWK/PhJ MGP_PWKPhJ_G0019503
 protein coding gene Chr13:37907873-37916610 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019333
 protein coding gene Chr13:37558451-37566984 (-)
WSB/EiJ MGP_WSBEiJ_G0019810
 protein coding gene Chr13:39249092-39257637 (-)



Homology
more
  • Human Ortholog
    GCM2, glial cells missing transcription factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCM2, glial cells missing transcription factor 2
  • Synonyms
    FIH2, GCMB, hGCMb, HRPT4
  • Links
    NCBI Gene ID: 9247
    neXtProt AC: NX_O75603
    UniProt: O75603

  • Chr Location
    6p24.2; chr6:10873223-10882041 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gcm2 mouse models; 2 with human GCM2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice lack parathyroid glands and exhibit hypocalcemia, hypophosphatemia, a mild abnormal bone phenotype, and partial perinatal lethality. Hypoparathyroidism is observed although parathyroid hormone serum levels are normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    994
  • Tissues
    216
  • cDNA Data
    14
  • Literature Summary
    49
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107889 NCBI Gene Model | MGI Sequence Detail 9609 C57BL/6J ±  kb
    transcript NM_008104 RefSeq | MGI Sequence Detail 2879 C57BL/6  
    polypeptide O09102 UniProt | EBI | MGI Sequence Detail 504 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 16
      Primer pair 9
      Other 8

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37080, MGI:108044
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 49
      Diseases 1
      Gene Ontology 13
      Phenotypes 20
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:327225 Nagakubo D, et al., Limits to in vivo fate changes of epithelia in thymus and parathyroid by ectopic expression of transcription factors Gcm2 and Foxn1. Sci Rep. 2022 Aug 8;12(1):13554
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory