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Rab27a Gene Detail
Summary
  • Symbol
    Rab27a
  • Name
    RAB27A, member RAS oncogene family
  • Synonyms
    2210402C08Rik, 2410003M20Rik, 4933437C11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861441
    NCBI Gene: 11891
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:72952136-73004911 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 40.08 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1769 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861441
 protein coding gene Chr9:72952092-73004911 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035025
 protein coding gene Chr9:73253815-73315687 (+)
A/J MGP_AJ_G0035006
 protein coding gene Chr9:70689903-70743479 (+)
AKR/J MGP_AKRJ_G0034935
 protein coding gene Chr9:72385213-72442060 (+)
BALB/cJ MGP_BALBcJ_G0034998
 protein coding gene Chr9:70396923-70449907 (+)
C3H/HeJ MGP_C3HHeJ_G0034707
 protein coding gene Chr9:72876931-72936127 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035517
 protein coding gene Chr9:75177052-75232000 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032428
 protein coding gene Chr9:70158900-70211258 (+)
CAST/EiJ MGP_CASTEiJ_G0034029
 protein coding gene Chr9:73219174-73276137 (+)
CBA/J MGP_CBAJ_G0034680
 protein coding gene Chr9:77787928-77840472 (+)
DBA/2J MGP_DBA2J_G0034839
 protein coding gene Chr9:70406766-70461675 (+)
FVB/NJ MGP_FVBNJ_G0034781
 protein coding gene Chr9:69716525-69772016 (+)
LP/J MGP_LPJ_G0034920
 protein coding gene Chr9:73472358-73530943 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034822
 protein coding gene Chr9:78872948-78935036 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035539
 protein coding gene Chr9:72537528-72601279 (+)
PWK/PhJ MGP_PWKPhJ_G0033733
 protein coding gene Chr9:70684522-70739839 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033566
 protein coding gene Chr9:72824267-72877834 (+)
WSB/EiJ MGP_WSBEiJ_G0034141
 protein coding gene Chr9:72472855-72530739 (+)



Homology
more
  • Human Ortholog
    RAB27A, RAB27A, member RAS oncogene family
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB27A, RAB27A, member RAS oncogene family
  • Synonyms
    GS2, HsT18676, RAB27, RAM
  • Links
    NCBI Gene ID: 5873
    neXtProt AC: NX_P51159
    UniProt: P51159

  • Chr Location
    15q21.3; chr15:55202966-55319113 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Rab27a mouse models; 2 with human RAB27A associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 2 models
      
IDs
 View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 7 alleles in 10 genetic backgrounds
    13 phenotypes from multigenic genotypes
    2 images
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes have abnormal melanocyte development producing abnormal pigmentation and a gray coat color.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    95
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    10
  • cDNA Data
    10
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032202 Ensembl Gene Model | MGI Sequence Detail 52776 C57BL/6J ±  kb
    transcript ENSMUST00000184146 Ensembl | MGI Sequence Detail 3168 Not Applicable  
    polypeptide ENSMUSP00000139310 Ensembl | MGI Sequence Detail 221 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1419, MGI:1918454, MGI:1919226, MGI:1922923, MGI:88083
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 5
      Diseases 4
      Gene Ontology 30
      Phenotypes 87
    • Earliest
      J:4458 Lane PW, et al., Ashen, a new color mutation on chromosome 9 of the mouse. J Hered. 1979;70(2):133-135
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory