H1f5 MGI Mouse Gene Detail - MGI:1861461 - H1.5 linker histone, cluster member

Symbol

H1f5
Name

H1.5 linker histone, cluster member
Synonyms

H1.5, H1B, H1f5, H1s-3, Hist1h1b

Feature Type

protein coding gene
IDs

MGI:1861461
NCBI Gene: 56702
Member of

Hist1 cluster
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:21964053-21964795 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 7.97 cM, cytoband A2-A3
Mapping Data

2 experiments

SNPs within 2kb

111 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1861461	protein coding gene	Chr13:21964002-21964795 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020296	protein coding gene	Chr13:19058051-19058793 (-)
A/J	MGP_AJ_G0020254	protein coding gene	Chr13:18635288-18636030 (-)
AKR/J	MGP_AKRJ_G0020226	protein coding gene	Chr13:18951851-18952593 (-)
BALB/cJ	MGP_BALBcJ_G0020240	protein coding gene	Chr13:18693212-18693954 (-)
C3H/HeJ	MGP_C3HHeJ_G0020046	protein coding gene	Chr13:19042241-19042983 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020683	protein coding gene	Chr13:19738239-19738981 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018292	protein coding gene	Chr13:16951823-16952564 (-)
CAST/EiJ	MGP_CASTEiJ_G0019578	protein coding gene	Chr13:18844304-18845046 (-)
CBA/J	MGP_CBAJ_G0020005	protein coding gene	Chr13:20410844-20411586 (-)
DBA/2J	MGP_DBA2J_G0020127	protein coding gene	Chr13:18267098-18267840 (-)
FVB/NJ	MGP_FVBNJ_G0020110	protein coding gene	Chr13:17928262-17929004 (-)
LP/J	MGP_LPJ_G0020199	protein coding gene	Chr13:19292130-19292871 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020143	protein coding gene	Chr13:20803990-20804732 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020713	protein coding gene	Chr13:18764037-18764779 (-)
PWK/PhJ	MGP_PWKPhJ_G0019336	protein coding gene	Chr13:18317558-18318300 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019148	protein coding gene	Chr13:17758354-17759095 (-)
WSB/EiJ	MGP_WSBEiJ_G0019634	protein coding gene	Chr13:18850344-18851086 (-)

Human Ortholog

H1-5, H1.5 linker histone, cluster member

Vertebrate Orthologs

9

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

H1-5, H1.5 linker histone, cluster member
Synonyms

H1, H1.5, H1B, H1F5, H1s-3, HIST1H1B
Links

HGNC:4719

NCBI Gene ID: 3009

neXtProt AC: NX_P16401

UniProt: P16401
Chr Location

6p22.1; chr6:27866792-27867588 (-) GRCh38

MGI Vertebrate Homology

H1f5 stringent orthology
1 human;1 mouse;1 rat;7 zebrafish
HCOP

vertebrate homology predictions: H1-5
Gene Tree

H1f5

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Genomic Mutations

2 involving H1f5
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

33
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

799
Tissues

9
cDNA Data

5
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS26295.1

Ensembl

ENSMUSG00000058773 (Evidence)
NCBI Gene

56702

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058773	Ensembl Gene Model \| MGI Sequence Detail	743	C57BL/6J	± kb
transcript	ENSMUST00000080511	Ensembl \| MGI Sequence Detail	743	Not Applicable
polypeptide	ENSMUSP00000079356	Ensembl \| MGI Sequence Detail	223	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008575 histone H1.5

(term hierarchy)
InterPro Domains

IPR005819 Linker histone H1/H5

IPR005818 Linker histone H1/H5, domain H15

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

P43276 1 site, 1 O-linked glycan (1 site)

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All nucleic 6

Genomic 1

cDNA 5

Microarray probesets 2

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MGI:6325005

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 11
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:249818 Izzo A, et al., Dynamic changes in H1 subtype composition during epigenetic reprogramming. J Cell Biol. 2017 Aug 9;

TSS for H1f5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121675	Chr13:21964786-21964802 (-)	1 bp
Tssr4006	Chr13:21964615-21964626 (-)	174 bp
Tssr121674	Chr13:21964318-21964355 (-)	458 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24