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H2az1 Gene Detail
Summary
  • Symbol
    H2az1
  • Name
    H2A.Z variant histone 1
  • Synonyms
    H2afz, H2A.Z, H2A.Z1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888388
    NCBI Gene: 51788
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:137570248-137572683 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 63.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888388
 protein coding gene Chr3:137570248-137572683 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027917
 protein coding gene Chr3:140885813-140888158 (+)
A/J MGP_AJ_G0027874
 protein coding gene Chr3:135912261-135914617 (+)
AKR/J MGP_AKRJ_G0027840
 protein coding gene Chr3:139522982-139526031 (+)
BALB/cJ MGP_BALBcJ_G0027887
 protein coding gene Chr3:135716452-135718721 (+)
C3H/HeJ MGP_C3HHeJ_G0027616
 protein coding gene Chr3:139844747-139858208 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028330
 protein coding gene Chr3:145753804-145757756 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025668
 protein coding gene Chr3:131015832-131018293 (+)
CAST/EiJ MGP_CASTEiJ_G0027072
 protein coding gene Chr3:139616131-139618280 (+)
CBA/J MGP_CBAJ_G0027593
 protein coding gene Chr3:150710753-150715856 (+)
DBA/2J MGP_DBA2J_G0027732
 protein coding gene Chr3:135034853-135037609 (+)
FVB/NJ MGP_FVBNJ_G0027699
 protein coding gene Chr3:132496097-132498658 (+)
LP/J MGP_LPJ_G0027842
 protein coding gene Chr3:142292391-142295220 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027731
 protein coding gene Chr3:158819958-158824496 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028388
 protein coding gene Chr3:139060761-139069394 (+)
PWK/PhJ MGP_PWKPhJ_G0026796
 protein coding gene Chr3:134779496-134783400 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026623
 protein coding gene Chr3:137156588-137158609 (+)
WSB/EiJ MGP_WSBEiJ_G0027152
 protein coding gene Chr3:139883298-139887867 (+)



Homology
more
  • Human Ortholog
    H2AZ1, H2A.Z variant histone 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H2AZ1, H2A.Z variant histone 1
  • Synonyms
    H2AFZ, H2A.z, H2A/z, H2AZ, H2A.Z-1
  • Links
    NCBI Gene ID: 3015
    neXtProt AC: NX_P0C0S5
    UniProt: P0C0S5

  • Chr Location
    4q23; chr4:99948086-99950355 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene results in an abnormal inner cell mass and early embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    46
  • cDNA Data
    24
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 51788 NCBI Gene Model | MGI Sequence Detail 2436 C57BL/6J ±  kb
    transcript NM_016750 RefSeq | MGI Sequence Detail 1069 C57BL/6  
    polypeptide P0C0S6 UniProt | EBI | MGI Sequence Detail 128 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 24
      Primer pair 7
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:6358822
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 10
      Phenotypes 28
    • Earliest
      J:64959 Misawa K, et al., A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3062-6
    • Latest
      J:354661 He XD, et al., Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development. Biol Reprod. 2024 Aug 28;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory