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Retn Gene Detail
Summary
  • Symbol
    Retn
  • Name
    resistin
  • Synonyms
    adipocyte-specific secretory factor, ADSF, Fizz3, rstn, Xcp4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888506
    NCBI Gene: 57264
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:3705770-3709818 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 1.92 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888506
 protein coding gene Chr8:3705770-3710110 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033313
 protein coding gene Chr8:601389-605787 (+)
A/J MGP_AJ_G0033296
 protein coding gene Chr8:572103-576432 (+)
AKR/J MGP_AKRJ_G0033227
 protein coding gene Chr8:602000-606340 (+)
BALB/cJ MGP_BALBcJ_G0033296
 protein coding gene Chr8:597880-602191 (+)
C3H/HeJ MGP_C3HHeJ_G0033010
 protein coding gene Chr8:614832-619320 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033806
 protein coding gene Chr8:648344-652809 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030779
 protein coding gene Chr8:524235-528356 (+)
CAST/EiJ MGP_CASTEiJ_G0032333
 protein coding gene Chr8:607173-611531 (+)
CBA/J MGP_CBAJ_G0032983
 protein coding gene Chr8:663533-667892 (+)
DBA/2J MGP_DBA2J_G0033137
 protein coding gene Chr8:542716-547201 (+)
FVB/NJ MGP_FVBNJ_G0033084
 protein coding gene Chr8:591749-596058 (+)
LP/J MGP_LPJ_G0033229
 protein coding gene Chr8:585647-590002 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033119
 protein coding gene Chr8:640353-645907 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033824
 protein coding gene Chr8:594537-599229 (+)
PWK/PhJ MGP_PWKPhJ_G0032043
 protein coding gene Chr8:570953-575546 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031887
 protein coding gene Chr8:584076-588623 (+)
WSB/EiJ MGP_WSBEiJ_G0032446
 protein coding gene Chr8:591283-595620 (+)



Homology
more
  • Human Ortholog
    RETN, resistin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RETN, resistin
  • Synonyms
    ADSF, FIZZ3, RENT, RETN1, RSTN, XCP1
  • Links
    NCBI Gene ID: 56729
    neXtProt AC: NX_Q9HD89
    UniProt: Q9HD89

  • Chr Location
    19p13.2; chr19:7669049-7670455 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human RETN associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired gluconeogenesis, lower fasting blood glucose levels, and a weaker positive correlation between body weight and blood glucose.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    6
  • cDNA Data
    45
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57264 NCBI Gene Model | MGI Sequence Detail 4049 C57BL/6J ±  kb
    transcript NM_022984 RefSeq | MGI Sequence Detail 1139 ZRU/MplStud  
    polypeptide Q99P87 UniProt | EBI | MGI Sequence Detail 114 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 1
      cDNA 46
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:63867 Holcomb IN, et al., FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000 Aug 1;19(15):4046-55
    • Latest
      J:335111 Zhao B, et al., Resistin deletion protects against heart failure injury by targeting DNA damage response. Cardiovasc Res. 2022 Jun 29;118(8):1947-1963
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory