Tob2 MGI Mouse Gene Detail - MGI:1888525

Symbol

Tob2
Name

transducer of ERBB2, 2
Synonyms

2900090N22Rik, 4930545K18Rik, mKIAA1663

Feature Type

protein coding gene
IDs

MGI:1888525
NCBI Gene: 57259
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:81732473-81742997 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.26 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

303 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888525	protein coding gene	Chr15:81732471-81744742 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022122	protein coding gene	Chr15:82317322-82327373 (-)
A/J	MGP_AJ_G0022083	protein coding gene	Chr15:79411546-79421606 (-)
AKR/J	MGP_AKRJ_G0022058	protein coding gene	Chr15:81605405-81615464 (-)
BALB/cJ	MGP_BALBcJ_G0022089	protein coding gene	Chr15:79451731-79461796 (-)
C3H/HeJ	MGP_C3HHeJ_G0021860	protein coding gene	Chr15:81624937-81635059 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022532	protein coding gene	Chr15:85554981-85565438 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020060	protein coding gene	Chr15:75859176-75869606 (-)
CAST/EiJ	MGP_CASTEiJ_G0021379	protein coding gene	Chr15:82402490-82412748 (-)
CBA/J	MGP_CBAJ_G0021824	protein coding gene	Chr15:88208820-88222095 (-)
DBA/2J	MGP_DBA2J_G0021954	protein coding gene	Chr15:78884129-78894017 (-)
FVB/NJ	MGP_FVBNJ_G0021931	protein coding gene	Chr15:77926187-77936088 (-)
LP/J	MGP_LPJ_G0022022	protein coding gene	Chr15:82466570-82476620 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021952	protein coding gene	Chr15:93149329-93159373 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022546	protein coding gene	Chr15:81706671-81716743 (-)
PWK/PhJ	MGP_PWKPhJ_G0021122	protein coding gene	Chr15:78924607-78935318 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020961	protein coding gene	Chr15:81491675-81501807 (-)
WSB/EiJ	MGP_WSBEiJ_G0021432	protein coding gene	Chr15:82119418-82130908 (-)

Human Ortholog

TOB2, transducer of ERBB2, 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TOB2, transducer of ERBB2, 2
Synonyms

APRO5, TOB4, TOBL, TROB2
Links

HGNC:11980

NCBI Gene ID: 10766

neXtProt AC: NX_Q14106

UniProt: Q14106
Chr Location

22q13.2; chr22:41433494-41446801 (-) GRCh38

MGI Vertebrate Homology

Tob2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TOB2
Gene Tree

Tob2

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References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

5
Radiation induced

2
Targeted

5
Genomic Mutations

3 involving Tob2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted mutation display reduced bone mass due to increased osteoclast numbers and acceleration of the bone resorption rate.

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

33
cDNA Data

103
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tob2

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All Sequences

59
RefSeq

6
UniProt

6
CCDS

CCDS27673.1

Ensembl

ENSMUSG00000048546 (Evidence)
NCBI Gene

57259

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048546	Ensembl Gene Model \| MGI Sequence Detail	10525	C57BL/6J	± kb
transcript	ENSMUST00000050467	Ensembl \| MGI Sequence Detail	4151	Not Applicable
polypeptide	ENSMUSP00000061390	Ensembl \| MGI Sequence Detail	345	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000016526 protein Tob2

(term hierarchy)
InterPro Domains

IPR002087 Anti-proliferative protein

IPR009818 Ataxin-2, C-terminal

IPR036054 BTG-like domain superfamily

IPR015676 Tob1/2
GlyGen

Q9JM55 1 site, 1 O-linked glycan (1 site)

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All nucleic 110

cDNA 108

Primer pair 1

Other 1

Microarray probesets 8

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MGI:1920339, MGI:1925282, MGI:2146166

Summaries

All 66

Developmental Gene Expression 6

Diseases 1

Gene Ontology 4

Phenotypes 32
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:346062 Perez RC, et al., TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells. J Mol Histol. 2024 Feb;55(1):121-138

TSS for Tob2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135507	Chr15:81742987-81743004 (-)	1 bp
Tssr135506	Chr15:81742733-81742742 (-)	259 bp
Tssr135505	Chr15:81742518-81742529 (-)	473 bp
Tssr135504	Chr15:81742463-81742481 (-)	525 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24