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Tbx21 Gene Detail
Summary
  • Symbol
    Tbx21
  • Name
    T-box 21
  • Synonyms
    T-bet, Tbet, Tblym, TBT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888984
    NCBI Gene: 57765
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96988897-97006157 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 60.95 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    547 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888984
 protein coding gene Chr11:96988833-97006157 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019024
 protein coding gene Chr11:99480763-99499508 (-)
A/J MGP_AJ_G0018992
 protein coding gene Chr11:95408940-95426095 (-)
AKR/J MGP_AKRJ_G0018962
 protein coding gene Chr11:98372394-98390846 (-)
BALB/cJ MGP_BALBcJ_G0018965
 protein coding gene Chr11:95897136-95914187 (-)
C3H/HeJ MGP_C3HHeJ_G0018779
 protein coding gene Chr11:98479474-98497645 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019417
 protein coding gene Chr11:102563213-102586071 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017048
 protein coding gene Chr11:92869565-92887168 (-)
CAST/EiJ MGP_CASTEiJ_G0018332
 protein coding gene Chr11:99332594-99351512 (-)
CBA/J MGP_CBAJ_G0018750
 protein coding gene Chr11:106794478-106813326 (-)
DBA/2J MGP_DBA2J_G0018858
 protein coding gene Chr11:94959296-94976669 (-)
FVB/NJ MGP_FVBNJ_G0018847
 protein coding gene Chr11:94441541-94458833 (-)
LP/J MGP_LPJ_G0018928
 protein coding gene Chr11:100008709-100028127 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018874
 protein coding gene Chr11:106693003-106712624 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019457
 protein coding gene Chr11:98657345-98677904 (-)
PWK/PhJ MGP_PWKPhJ_G0018104
 protein coding gene Chr11:95932497-95950120 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017894
 protein coding gene Chr11:98375220-98393446 (-)
WSB/EiJ MGP_WSBEiJ_G0018382
 protein coding gene Chr11:98568375-98587729 (-)



Homology
more
  • Human Ortholog
    TBX21, T-box transcription factor 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBX21, T-box transcription factor 21
  • Synonyms
    IMD88, T-bet, TBET, TBLYM, T-PET
  • Links
    NCBI Gene ID: 30009
    neXtProt AC: NX_Q9UL17
    UniProt: Q9UL17

  • Chr Location
    17q21.32; chr17:47733236-47746122 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tbx21 mouse models; 2 with human TBX21 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 5 alleles in 8 genetic backgrounds
    35 phenotypes from multigenic genotypes
    1 images
    372 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display defects in the production of NK and NK-T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    59
  • cDNA Data
    9
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001444 Ensembl Gene Model | MGI Sequence Detail 17261 C57BL/6J ±  kb
    transcript ENSMUST00000001484 Ensembl | MGI Sequence Detail 2488 Not Applicable  
    polypeptide ENSMUSP00000001484 Ensembl | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 3
      cDNA 10
      Primer pair 2
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 498
      Developmental Gene Expression 32
      Diseases 2
      Gene Ontology 17
      Phenotypes 372
    • Earliest
      J:105228 Zhumabekov T, et al., Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J Immunol Methods. 1995 Sep 11;185(1):133-40
    • Latest
      J:352379 Lee S, et al., CRIF1 deficiency induces FOXP3(LOW) inflammatory non-suppressive regulatory T cells, thereby promoting antitumor immunity. Sci Adv. 2024 Mar 29;10(13):eadj9600
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory