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Api5 Gene Detail
Summary
  • Symbol
    Api5
  • Name
    apoptosis inhibitor 5
  • Synonyms
    AAC-11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888993
    NCBI Gene: 11800
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:94242073-94268490 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 51.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    626 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888993
 protein coding gene Chr2:94242027-94268490 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026186
 protein coding gene Chr2:95962892-95989874 (-)
A/J MGP_AJ_G0026147
 protein coding gene Chr2:92054845-92079101 (-)
AKR/J MGP_AKRJ_G0026128
 protein coding gene Chr2:94633229-94667042 (-)
BALB/cJ MGP_BALBcJ_G0026156
 protein coding gene Chr2:92255211-92279651 (-)
C3H/HeJ MGP_C3HHeJ_G0025907
 protein coding gene Chr2:94908404-94935058 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026607
 protein coding gene Chr2:99219326-99243758 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023998
 protein coding gene Chr2:88528860-88555240 (-)
CAST/EiJ MGP_CASTEiJ_G0025372
 protein coding gene Chr2:95528319-95552464 (-)
CBA/J MGP_CBAJ_G0025885
 protein coding gene Chr2:102702221-102729232 (-)
DBA/2J MGP_DBA2J_G0026021
 protein coding gene Chr2:91664167-91692179 (-)
FVB/NJ MGP_FVBNJ_G0025984
 protein coding gene Chr2:90781703-90809927 (-)
LP/J MGP_LPJ_G0026125
 protein coding gene Chr2:96157716-96183131 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026010
 protein coding gene Chr2:105566234-105595153 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026661
 protein coding gene Chr2:94727045-94755776 (-)
PWK/PhJ MGP_PWKPhJ_G0025107
 protein coding gene Chr2:91423588-91448444 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024908
 protein coding gene Chr2:94282542-94306877 (-)
WSB/EiJ MGP_WSBEiJ_G0025439
 protein coding gene Chr2:95335528-95361659 (-)



Homology
more
  • Human Ortholog
    API5, apoptosis inhibitor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    API5, apoptosis inhibitor 5
  • Synonyms
    AAC-11, AAC11
  • Links
    NCBI Gene ID: 8539
    neXtProt AC: NX_Q9BZZ5
    UniProt: Q9BZZ5

  • Chr Location
    11p12; chr11:43311963-43344529 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from multigenic genotypes
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    29
  • cDNA Data
    17
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 11800 NCBI Gene Model | MGI Sequence Detail 26418 C57BL/6J ±  kb
transcript NM_001349003 RefSeq | MGI Sequence Detail 3755 C57BL/6  
polypeptide O35841 UniProt | EBI | MGI Sequence Detail 504 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2138859
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:340266 Matsuzawa-Ishimoto Y, et al., The gammadelta IEL effector API5 masks genetic susceptibility to Paneth cell death. Nature. 2022 Oct;610(7932):547-554
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory