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Fxyd4 Gene Detail
Summary
  • Symbol
    Fxyd4
  • Name
    FXYD domain-containing ion transport regulator 4
  • Synonyms
    0610008I02Rik, Chif
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889005
    NCBI Gene: 108017
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:117910520-117914653 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 55.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889005
 protein coding gene Chr6:117910519-117914668 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031181
 protein coding gene Chr6:120651641-120656150 (-)
A/J MGP_AJ_G0031150
 protein coding gene Chr6:116042598-116046688 (-)
AKR/J MGP_AKRJ_G0031081
 protein coding gene Chr6:119162308-119166421 (-)
BALB/cJ MGP_BALBcJ_G0031161
 protein coding gene Chr6:115819164-115823321 (-)
C3H/HeJ MGP_C3HHeJ_G0030548
 protein coding gene Chr6:65131721-65135787 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031619
 protein coding gene Chr6:123764273-123770944 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030268
 protein coding gene Chr6:119536616-119540747 (-)
CBA/J MGP_CBAJ_G0030844
 protein coding gene Chr6:128648161-128654905 (-)
DBA/2J MGP_DBA2J_G0031000
 protein coding gene Chr6:114941959-114946071 (-)
FVB/NJ MGP_FVBNJ_G0030952
 protein coding gene Chr6:114074390-114078513 (-)
LP/J MGP_LPJ_G0031079
 protein coding gene Chr6:120686631-120690772 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030986
 protein coding gene Chr6:132758400-132763596 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031648
 protein coding gene Chr6:119189183-119194432 (-)
PWK/PhJ MGP_PWKPhJ_G0029983
 protein coding gene Chr6:113949549-113953671 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029812
 protein coding gene Chr6:117900970-117905132 (-)
WSB/EiJ MGP_WSBEiJ_G0030351
 protein coding gene Chr6:119455537-119459615 (-)



Homology
more
  • Human Ortholog
    FXYD4, FXYD domain containing ion transport regulator 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FXYD4, FXYD domain containing ion transport regulator 4
  • Synonyms
    CHIF
  • Links
    NCBI Gene ID: 53828
    neXtProt AC: NX_P59646
    UniProt: P59646

  • Chr Location
    10q11.21; chr10:43371636-43376335 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable and fertile but exhibit a significant increase in urine volume (and water intake) under Na+ deprivation and K+ loading, as well as lethality after a combination of high-K+ intake and furosemide injection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004988 Ensembl Gene Model | MGI Sequence Detail 4134 C57BL/6J ±  kb
    transcript ENSMUST00000203433 Ensembl | MGI Sequence Detail 670 Not Applicable  
    polypeptide ENSMUSP00000144773 Ensembl | MGI Sequence Detail 99 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000030339 FXYD domain-containing ion transport regulator 4
      (term hierarchy)
    • InterPro Domains
      IPR047283 FXYD domain-containing ion transport regulator 4
      IPR000272 Ion-transport regulator, FXYD family
      IPR047297 Ion-transport regulator, FXYD motif
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1889805, MGI:1925611
    References
    more
    • Summaries
      All 35
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:64123 Sweadner KJ, et al., The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Genomics. 2000 Aug 15;68(1):41-56
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory