Cpq MGI Mouse Gene Detail - MGI:1889205

Symbol

Cpq
Name

carboxypeptidase Q
Synonyms

1190003P12Rik, 2610034C17Rik, HLS2, Lal-1, Pgcp

Feature Type

protein coding gene
IDs

MGI:1889205
NCBI Gene: 54381
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:33083275-33594698 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 13.74 cM, cytoband B3.2
Mapping Data

2 experiments

SNPs within 2kb

14317 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889205	protein coding gene	Chr15:33083275-33594698 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021773	protein coding gene	Chr15:31391959-31902351 (+)
A/J	MGP_AJ_G0021734	protein coding gene	Chr15:30144936-30659491 (+)
AKR/J	MGP_AKRJ_G0021711	protein coding gene	Chr15:30927903-31485666 (+)
BALB/cJ	MGP_BALBcJ_G0021740	protein coding gene	Chr15:30142536-30662464 (+)
C3H/HeJ	MGP_C3HHeJ_G0021515	protein coding gene	Chr15:30961321-31483376 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022179	protein coding gene	Chr15:32589866-33119116 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019717	protein coding gene	Chr15:28123106-28578657 (+)
CAST/EiJ	MGP_CASTEiJ_G0021031	protein coding gene	Chr15:31411408-31893956 (+)
CBA/J	MGP_CBAJ_G0021484	protein coding gene	Chr15:33532613-34104514 (+)
DBA/2J	MGP_DBA2J_G0021608	protein coding gene	Chr15:29949151-30440228 (+)
FVB/NJ	MGP_FVBNJ_G0021586	protein coding gene	Chr15:29440856-29930029 (+)
LP/J	MGP_LPJ_G0021677	protein coding gene	Chr15:31309871-31801389 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021611	protein coding gene	Chr15:36557830-37173297 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022202	protein coding gene	Chr15:31167824-31679568 (+)
PWK/PhJ	MGP_PWKPhJ_G0020775	protein coding gene	Chr15:30072755-30542240 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020613	protein coding gene	Chr15:30892142-31412889 (+)
WSB/EiJ	MGP_WSBEiJ_G0021087	protein coding gene	Chr15:31136708-31638384 (+)

Human Ortholog

CPQ, carboxypeptidase Q

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CPQ, carboxypeptidase Q
Synonyms

LDP, PGCP
Links

HGNC:16910

NCBI Gene ID: 10404

neXtProt AC: NX_Q9Y646

UniProt: Q9Y646
Chr Location

8q22.1; chr8:96645242-97149654 (+) GRCh38

MGI Vertebrate Homology

Cpq stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CPQ
Gene Tree

Cpq

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

3
Genomic Mutations

2 involving Cpq
Incidental Mutations

APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

34
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

15
cDNA Data

87
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cpq

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All Sequences

57
RefSeq

4
UniProt

5
CCDS

CCDS27414.1

Ensembl

ENSMUSG00000039007 (Evidence)
NCBI Gene

54381

			Length	Strain/Species	Flank
genomic	54381	NCBI Gene Model \| MGI Sequence Detail	511424	C57BL/6J	± kb
transcript	NM_018755	RefSeq \| MGI Sequence Detail	2013	C57BL/6
polypeptide	Q9WVJ3	UniProt \| EBI \| MGI Sequence Detail	470	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012603 carboxypeptidase Q

(term hierarchy)
EC

3.4.17.-
InterPro Domains

IPR039866 Carboxypeptidase Q

IPR007484 Peptidase M28
GlyGen

Q9WVJ3 4 sites, 5 N-linked glycans (1 site), 1 O-linked glycan (1 site)

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All nucleic 88

cDNA 88

Microarray probesets 5

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MGI:1916490, MGI:1923585

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cpq:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130997	Chr15:33083256-33083293 (+)	0 bp
Tssr130998	Chr15:33083300-33083312 (+)	31 bp
Tssr130999	Chr15:33083359-33083441 (+)	125 bp
Tssr131001	Chr15:33282285-33282298 (+)	199,017 bp
Tssr4574	Chr15:33465295-33465296 (+)	382,021 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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