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Skap2 Gene Detail
Summary
  • Symbol
    Skap2
  • Name
    src family associated phosphoprotein 2
  • Synonyms
    2610021A10Rik, mSKAP55R, RA70, Saps, SKAP-HOM
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889206
    NCBI Gene: 54353
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:51836145-51989529 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.35 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3624 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889206
 protein coding gene Chr6:51834402-51989529 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030737
 protein coding gene Chr6:51070631-51230570 (-)
A/J MGP_AJ_G0030707
 protein coding gene Chr6:48686870-48843032 (-)
AKR/J MGP_AKRJ_G0030633
 protein coding gene Chr6:50387855-50547382 (-)
BALB/cJ MGP_BALBcJ_G0030718
 protein coding gene Chr6:49046617-49203701 (-)
C3H/HeJ MGP_C3HHeJ_G0030432
 protein coding gene Chr6:50395652-50556747 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031173
 protein coding gene Chr6:52204332-52365111 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028380
 protein coding gene Chr6:46339963-46493751 (-)
CAST/EiJ MGP_CASTEiJ_G0029834
 protein coding gene Chr6:50191076-50354578 (-)
CBA/J MGP_CBAJ_G0030405
 protein coding gene Chr6:54381523-54548460 (-)
DBA/2J MGP_DBA2J_G0030555
 protein coding gene Chr6:48607358-48764275 (-)
FVB/NJ MGP_FVBNJ_G0030507
 protein coding gene Chr6:48225251-48379500 (-)
LP/J MGP_LPJ_G0030640
 protein coding gene Chr6:51050912-51213054 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030541
 protein coding gene Chr6:57032976-57210110 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031203
 protein coding gene Chr6:50306055-50465391 (-)
PWK/PhJ MGP_PWKPhJ_G0029547
 protein coding gene Chr6:48221297-48376507 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029382
 protein coding gene Chr6:49649905-49803721 (-)
WSB/EiJ MGP_WSBEiJ_G0029911
 protein coding gene Chr6:50316088-50475030 (-)



Homology
more
  • Human Ortholog
    SKAP2, src kinase associated phosphoprotein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SKAP2, src kinase associated phosphoprotein 2
  • Synonyms
    PRAP, RA70, SAPS, SCAP2, SKAP55R, SKAP-HOM
  • Links
    NCBI Gene ID: 8935
    neXtProt AC: NX_O75563
    UniProt: O75563

  • Chr Location
    7p15.2; chr7:26654770-26995239 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are embryonic lethal. Homozygotes for a gene-trapped allele show impaired B-cell responses and B-cell adhesion, decreased susceptibility to EAE, abnormal dendritic cell physiology, fast extinction of fear memory, and impaired social memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    6
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54353 NCBI Gene Model | MGI Sequence Detail 153385 C57BL/6J ±  kb
    transcript NM_018773 RefSeq | MGI Sequence Detail 1656 FVB/N  
    polypeptide Q3UND0 UniProt | EBI | MGI Sequence Detail 358 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 9
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1889379, MGI:1922074, MGI:3035219
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
    • Latest
      J:327901 Ye Q, et al., Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory