Eral1 MGI Mouse Gene Detail - MGI:1889295 - Era like 12S mitochondrial rRNA chaperone 1

Symbol

Eral1
Name

Era like 12S mitochondrial rRNA chaperone 1
Synonyms

2610524P08Rik, 9130407C09Rik, MERA-S, MERA-W

Feature Type

protein coding gene
IDs

MGI:1889295
NCBI Gene: 57837
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:77964202-77971209 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM
Mapping Data

3 experiments

SNPs within 2kb

235 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889295	protein coding gene	Chr11:77964202-77971209 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018762	protein coding gene	Chr11:79042057-79051660 (-)
A/J	MGP_AJ_G0018728	protein coding gene	Chr11:76029755-76036465 (-)
AKR/J	MGP_AKRJ_G0018698	protein coding gene	Chr11:78334706-78341514 (-)
BALB/cJ	MGP_BALBcJ_G0018702	protein coding gene	Chr11:76425810-76435483 (-)
C3H/HeJ	MGP_C3HHeJ_G0018515	protein coding gene	Chr11:78371150-78377881 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019153	protein coding gene	Chr11:81510998-81524563 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016788	protein coding gene	Chr11:73004036-73010626 (-)
CAST/EiJ	MGP_CASTEiJ_G0018069	protein coding gene	Chr11:78810254-78817241 (-)
CBA/J	MGP_CBAJ_G0018485	protein coding gene	Chr11:85068106-85074703 (-)
DBA/2J	MGP_DBA2J_G0018594	protein coding gene	Chr11:75611446-75618870 (-)
FVB/NJ	MGP_FVBNJ_G0018584	protein coding gene	Chr11:75195161-75202543 (-)
LP/J	MGP_LPJ_G0018665	protein coding gene	Chr11:79579698-79589220 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018610	protein coding gene	Chr11:85503902-85512516 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019193	protein coding gene	Chr11:78573300-78580085 (-)
PWK/PhJ	MGP_PWKPhJ_G0017840	protein coding gene	Chr11:76389060-76395977 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017631	protein coding gene	Chr11:78181244-78188246 (-)
WSB/EiJ	MGP_WSBEiJ_G0018122	protein coding gene	Chr11:78386597-78395698 (-)

Human Ortholog

ERAL1, Era like 12S mitochondrial rRNA chaperone 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ERAL1, Era like 12S mitochondrial rRNA chaperone 1
Synonyms

CEGA, ERA, ERAL1A, ERAL1B, ERA-W, H-ERA, HERA-A, HERA-B, PRLTS6
Links

HGNC:3424

NCBI Gene ID: 26284

neXtProt AC: NX_O75616

UniProt: O75616
Chr Location

17q11.2; chr17:28855010-28861061 (+) GRCh38

MGI Vertebrate Homology

Eral1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ERAL1
Gene Tree

Eral1

Diseases

1 with human ERAL1 associations

				Human Disease	Mouse Models
				Perrault syndrome 6 IDs Perrault syndrome 6 DOID:0080256 OMIM:617565

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

1
Genomic Mutations

2 involving Eral1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

41
cDNA Data

59
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eral1

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All Sequences

47
RefSeq

2
UniProt

3
CCDS

CCDS48856.1

Ensembl

ENSMUSG00000020832 (Evidence)
NCBI Gene

57837

			Length	Strain/Species	Flank
genomic	57837	NCBI Gene Model \| MGI Sequence Detail	7008	C57BL/6J	± kb
transcript	NM_022313	RefSeq \| MGI Sequence Detail	2055	C57BL/6
polypeptide	Q9CZU4	UniProt \| EBI \| MGI Sequence Detail	437	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007154 GTP-binding protein era

(term hierarchy)
InterPro Domains

IPR030388 Era-type guanine nucleotide-binding (G) domain

IPR005662 GTPase Era

IPR006073 GTP binding domain

IPR015946 K homology domain-like, alpha/beta

IPR009019 K homology domain superfamily, prokaryotic type

IPR004044 K Homology domain, type 2

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR005225 Small GTP-binding protein domain

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All nucleic 62

Genomic 1

cDNA 61

Microarray probesets 6

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MGI:1918860, MGI:1919411, MGI:2144397

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Eral1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109370	Chr11:77971186-77971213 (-)	9 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24