Akirin2 MGI Mouse Gene Detail - MGI:1889364

Symbol

Akirin2
Name

akirin 2
Synonyms

2700059D21Rik

Feature Type

protein coding gene
IDs

MGI:1889364
NCBI Gene: 433693
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:34550937-34566908 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 16.80 cM
Mapping Data

2 experiments

SNPs within 2kb

340 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889364	protein coding gene	Chr4:34550615-34566930 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028126	protein coding gene	Chr4:32134016-32150862 (+)
A/J	MGP_AJ_G0028084	protein coding gene	Chr4:30952147-30967771 (+)
AKR/J	MGP_AKRJ_G0028047	protein coding gene	Chr4:31776510-31792046 (+)
BALB/cJ	MGP_BALBcJ_G0028095	protein coding gene	Chr4:31241560-31257418 (+)
C3H/HeJ	MGP_C3HHeJ_G0027824	protein coding gene	Chr4:32092885-32109045 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028537	protein coding gene	Chr4:33357421-33375881 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025878	protein coding gene	Chr4:29077367-29093635 (+)
CAST/EiJ	MGP_CASTEiJ_G0027279	protein coding gene	Chr4:31882016-31900391 (+)
CBA/J	MGP_CBAJ_G0027796	protein coding gene	Chr4:34430890-34449524 (+)
DBA/2J	MGP_DBA2J_G0027940	protein coding gene	Chr4:30947453-30963083 (+)
FVB/NJ	MGP_FVBNJ_G0027906	protein coding gene	Chr4:30363084-30378574 (+)
LP/J	MGP_LPJ_G0028048	protein coding gene	Chr4:32219798-32236382 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027939	protein coding gene	Chr4:37041174-37056682 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028596	protein coding gene	Chr4:31802647-31820175 (+)
PWK/PhJ	MGP_PWKPhJ_G0026998	protein coding gene	Chr4:30956757-30972937 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026827	protein coding gene	Chr4:31663871-31679262 (+)
WSB/EiJ	MGP_WSBEiJ_G0027355	protein coding gene	Chr4:31803660-31820162 (+)

Human Ortholog

AKIRIN2, akirin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AKIRIN2, akirin 2
Synonyms

C6orf166, dJ486L4.2, FBI1
Links

HGNC:21407

NCBI Gene ID: 55122

neXtProt AC: NX_Q53H80

UniProt: Q53H80
Chr Location

6q15; chr6:87674860-87702233 (-) GRCh38

MGI Vertebrate Homology

Akirin2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AKIRIN2
Gene Tree

Akirin2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically and radiation induced

1
Endonuclease-mediated

2
Gene trapped

11
Targeted

3
Genomic Mutations

1 involving Akirin2
Find Mice (IMSR)

23 strains or lines available

No homozygous null embryos are recovered at E9.5.

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All GO Annotations

52
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

5
cDNA Data

11
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase akirin2

ZFIN akirin2

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All Sequences

42
RefSeq

4
UniProt

1
CCDS

CCDS18027.1

Ensembl

ENSMUSG00000028291 (Evidence)
NCBI Gene

433693

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028291	Ensembl Gene Model \| MGI Sequence Detail	15972	C57BL/6J	± kb
transcript	ENSMUST00000084299	Ensembl \| MGI Sequence Detail	1397	Not Applicable
polypeptide	ENSMUSP00000081322	Ensembl \| MGI Sequence Detail	201	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003898 akirin-2

(term hierarchy)
InterPro Domains

IPR024132 Akirin

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All nucleic 11

cDNA 11

Microarray probesets 3

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MGI:1914435, MGI:2140455, MGI:3034236

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 16
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:327544 Peek SL, et al., p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2. iScience. 2022 Feb 18;25(2):103814

TSS for Akirin2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36766	Chr4:34550587-34550662 (+)	-312 bp
Tssr36767	Chr4:34550677-34550688 (+)	-254 bp
Tssr36768	Chr4:34550900-34550916 (+)	-29 bp
Tssr36769	Chr4:34550918-34550929 (+)	-13 bp
Tssr36770	Chr4:34550931-34550945 (+)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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