Il17re MGI Mouse Gene Detail - MGI:1889371

Symbol

Il17re
Name

interleukin 17 receptor E
Synonyms

Il25r

Feature Type

protein coding gene
IDs

MGI:1889371
NCBI Gene: 57890
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr6:113435659-113447719 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 52.76 cM
Mapping Data

2 experiments

SNPs within 2kb

458 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889371	protein coding gene	Chr6:113435445-113447719 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031125	protein coding gene	Chr6:115978714-115992187 (+)
A/J	MGP_AJ_G0031094	protein coding gene	Chr6:111535549-111547808 (+)
AKR/J	MGP_AKRJ_G0031025	protein coding gene	Chr6:114529447-114541689 (+)
BALB/cJ	MGP_BALBcJ_G0031105	protein coding gene	Chr6:111481561-111493817 (+)
C3H/HeJ	MGP_C3HHeJ_G0030603	protein coding gene	Chr6:69756403-69768903 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031564	protein coding gene	Chr6:118983057-118995329 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028728	protein coding gene	Chr6:108563250-108575732 (+)
CAST/EiJ	MGP_CASTEiJ_G0030212	protein coding gene	Chr6:114973923-114987598 (+)
CBA/J	MGP_CBAJ_G0030791	protein coding gene	Chr6:123678441-123690693 (+)
DBA/2J	MGP_DBA2J_G0030944	protein coding gene	Chr6:110614958-110627216 (+)
FVB/NJ	MGP_FVBNJ_G0030898	protein coding gene	Chr6:109617051-109629317 (+)
LP/J	MGP_LPJ_G0031024	protein coding gene	Chr6:116015403-116027385 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030932	protein coding gene	Chr6:127942842-127955109 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031591	protein coding gene	Chr6:114543786-114556044 (+)
PWK/PhJ	MGP_PWKPhJ_G0029928	protein coding gene	Chr6:109570939-109583427 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029756	protein coding gene	Chr6:113361273-113374560 (+)
WSB/EiJ	MGP_WSBEiJ_G0030296	protein coding gene	Chr6:114918657-114930662 (+)

Human Ortholog

IL17RE, interleukin 17 receptor E

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL17RE, interleukin 17 receptor E
Links

HGNC:18439

NCBI Gene ID: 132014

neXtProt AC: NX_Q8NFR9

UniProt: Q8NFR9
Chr Location

3p25.3; chr3:9902093-9916402 (+) GRCh38

MGI Vertebrate Homology

Il17re stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IL17RE
Gene Tree

Il17re

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Phenotype Summary

11 phenotypes from 3 alleles in 2 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Spontaneous

1
Targeted

5
Transgenic

1
Genomic Mutations

1 involving Il17re
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice exhibit increased susceptibility to DSS-induced colitis, imiquimod-induced psoriasis, and C. rodentium bacterial infection.

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All GO Annotations

8
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

8
cDNA Data

38
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

64
RefSeq

14
UniProt

2
CCDS

CCDS20420.1, CCDS20421.1, CCDS90101.1, CCDS90102.1

Ensembl

ENSMUSG00000043088 (Evidence)
NCBI Gene

57890

			Length	Strain/Species	Flank
genomic	57890	NCBI Gene Model \| MGI Sequence Detail	12061	C57BL/6J	± kb
transcript	NM_001034031	RefSeq \| MGI Sequence Detail	2712	C57BL/6
polypeptide	Q8BH06	UniProt \| EBI \| MGI Sequence Detail	637	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008985 interleukin-17 receptor E

(term hierarchy)
InterPro Domains

IPR027841 Interleukin-17 receptor C/E, N-terminal

IPR039465 Interleukin-17 receptor-like

IPR013568 SEFIR domain
GlyGen

Q8BH06 2 sites

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All nucleic 38

cDNA 38

Microarray probesets 4

Summaries

All 54

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 23
Earliest

J:87486 Akeson EC, Chromosomal inversion discovered in C3H/HeJ mice. JAX Notes. 2003;491:15
Latest

J:344781 Wang J, et al., Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model. Am J Pathol. 2022 Feb;192(2):332-343

TSS for Il17re:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58214	Chr6:113435726-113435797 (+)	103 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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