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B3gnt2 Gene Detail
Summary
  • Symbol
    B3gnt2
  • Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
  • Synonyms
    B3Galt6, B3gnt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889505
    NCBI Gene: 53625
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:22784739-22810336 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 14.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    745 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889505
 protein coding gene Chr11:22709738-22810961 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018080
 protein coding gene Chr11:20536877-20565389 (-)
A/J MGP_AJ_G0018053
 protein coding gene Chr11:19758293-19784701 (-)
AKR/J MGP_AKRJ_G0018017
 protein coding gene Chr11:20459407-20490162 (-)
BALB/cJ MGP_BALBcJ_G0018021
 protein coding gene Chr11:19895064-19921092 (-)
C3H/HeJ MGP_C3HHeJ_G0017835
 protein coding gene Chr11:20338995-20369755 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018473
 protein coding gene Chr11:21396116-21423302 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016131
 protein coding gene Chr11:18653543-18679401 (-)
CAST/EiJ MGP_CASTEiJ_G0017396
 protein coding gene Chr11:20398668-20424673 (-)
CBA/J MGP_CBAJ_G0017809
 protein coding gene Chr11:22344740-22373636 (-)
DBA/2J MGP_DBA2J_G0017919
 protein coding gene Chr11:19685289-19711462 (-)
FVB/NJ MGP_FVBNJ_G0017911
 protein coding gene Chr11:19460141-19486568 (-)
LP/J MGP_LPJ_G0017990
 protein coding gene Chr11:20656641-20683665 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017937
 protein coding gene Chr11:22822896-22850018 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018514
 protein coding gene Chr11:20578494-20604479 (-)
PWK/PhJ MGP_PWKPhJ_G0017177
 protein coding gene Chr11:19725712-19752643 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016973
 protein coding gene Chr11:20308651-20335704 (-)
WSB/EiJ MGP_WSBEiJ_G0017450
 protein coding gene Chr11:20202163-20228219 (-)



Homology
more
  • Human Ortholog
    B3GNT2, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    B3GNT2, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
  • Synonyms
    3-Gn-T1, 3-Gn-T2, B3GNT, B3GNT1, B3GN-T2, B3GNT-2, beta-1, BETA3GNT, beta3Gn-T1, beta3Gn-T2, BGnT-2, BGNT2
  • Links
    NCBI Gene ID: 10678
    neXtProt AC: NX_Q9NY97
    UniProt: Q9NY97

  • Chr Location
    2p15; chr2:62196115-62224731 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene trap allele show severe axon guidance errors and specific loss of olfactory sensory neurons and glomeruli. Homozygotes for another gene trap allele show hyperactive lymphocytes and macrophages. Homozygotes for a reporter allele display behavioral despair and reduced anxiety.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    161
  • cDNA Data
    13
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53625 NCBI Gene Model | MGI Sequence Detail 25598 C57BL/6J ±  kb
    transcript NM_016888 RefSeq | MGI Sequence Detail 2699 ZRU/MplStud  
    polypeptide Q9Z222 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1890585, MGI:2143981, MGI:2143995, MGI:2144521
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:234082 Mkhikian H, et al., Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis. Elife. 2016;5:e14814
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory