Eid1 MGI Mouse Gene Detail - MGI:1889651 - EP300 interacting inhibitor of differentiation 1

Symbol

Eid1
Name

EP300 interacting inhibitor of differentiation 1
Synonyms

2610002K20Rik, Cri1, EID-1, ORF12

Feature Type

protein coding gene
IDs

MGI:1889651
NCBI Gene: 58521
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr2:125515015-125516705 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.76 cM
Mapping Data

1 experiment

SNPs within 2kb

119 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889651	protein coding gene	Chr2:125515015-125517563 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026432	protein coding gene	Chr2:128873057-128874747 (+)
A/J	MGP_AJ_G0026395	protein coding gene	Chr2:123623630-123625321 (+)
AKR/J	MGP_AKRJ_G0026371	protein coding gene	Chr2:127152785-127154486 (+)
BALB/cJ	MGP_BALBcJ_G0026407	protein coding gene	Chr2:123914210-123915900 (+)
C3H/HeJ	MGP_C3HHeJ_G0026151	protein coding gene	Chr2:127641304-127642990 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026853	protein coding gene	Chr2:132976566-132978256 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024230	protein coding gene	Chr2:118399237-118400924 (+)
CAST/EiJ	MGP_CASTEiJ_G0025612	protein coding gene	Chr2:127888672-127890358 (+)
CBA/J	MGP_CBAJ_G0026131	protein coding gene	Chr2:137796869-137798555 (+)
DBA/2J	MGP_DBA2J_G0026265	protein coding gene	Chr2:123038579-123040265 (+)
FVB/NJ	MGP_FVBNJ_G0026229	protein coding gene	Chr2:121726504-121728194 (+)
LP/J	MGP_LPJ_G0026370	protein coding gene	Chr2:129104628-129106318 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026249	protein coding gene	Chr2:141920018-141921708 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026908	protein coding gene	Chr2:127191815-127193505 (+)
PWK/PhJ	MGP_PWKPhJ_G0025348	protein coding gene	Chr2:122578379-122580069 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025150	protein coding gene	Chr2:126268657-126270344 (+)
WSB/EiJ	MGP_WSBEiJ_G0025686	protein coding gene	Chr2:128094473-128096164 (+)

Human Ortholog

EID1, EP300 interacting inhibitor of differentiation 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EID1, EP300 interacting inhibitor of differentiation 1
Synonyms

C15orf3, CRI1, EID-1, IRO45620, PNAS-22, PTD014, RBP21
Links

HGNC:1191

NCBI Gene ID: 23741

neXtProt AC: NX_Q9Y6B2

UniProt: Q9Y6B2
Chr Location

15q21.1; chr15:48878134-48880173 (+) GRCh38

MGI Vertebrate Homology

Eid1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: EID1
Gene Tree

Eid1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Eid1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit lower neonatal survival rate, impaired spatial learning , smaller neonatal telencephalon volume, decreased neural stem cell proliferation rate.

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

10
cDNA Data

21
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

53
RefSeq

2
UniProt

2
CCDS

CCDS50696.1

Ensembl

ENSMUSG00000091337 (Evidence)
NCBI Gene

58521

			Length	Strain/Species	Flank
genomic	ENSMUSG00000091337	Ensembl Gene Model \| MGI Sequence Detail	1691	C57BL/6J	± kb
transcript	ENSMUST00000164756	Ensembl \| MGI Sequence Detail	1691	Not Applicable
polypeptide	ENSMUSP00000129413	Ensembl \| MGI Sequence Detail	159	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006951 EP300-interacting inhibitor of differentiation 1

(term hierarchy)
PDB

4NUF
InterPro Domains

IPR033258 EP300-interacting inhibitor of differentiation

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All nucleic 21

cDNA 21

Microarray probesets 5

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MGI:1913769

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 6
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:292215 Fu X, et al., Transcriptome profiling in Eid1-KO mice brain shows that Eid1 links cell proliferation in the brain. Gene. 2019 Oct 30;717:143998

TSS for Eid1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19899	Chr2:125514997-125515053 (+)	10 bp
Tssr19900	Chr2:125515069-125515104 (+)	72 bp
Tssr19901	Chr2:125515603-125515614 (+)	594 bp
Tssr19902	Chr2:125515974-125515994 (+)	969 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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