Gsdme MGI Mouse Gene Detail - MGI:1889850

Symbol

Gsdme
Name

gasdermin E
Synonyms

2310037D07Rik, 4932441K13Rik, Dfna5, Dfna5h, Fin15

Feature Type

protein coding gene
IDs

MGI:1889850
NCBI Gene: 54722
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:50167013-50240837 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 24.13 cM
Mapping Data

5 experiments

SNPs within 2kb

2079 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889850	protein coding gene	Chr6:50165868-50240842 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030728	protein coding gene	Chr6:49284534-49360503 (-)
A/J	MGP_AJ_G0030699	protein coding gene	Chr6:46988170-47066165 (-)
AKR/J	MGP_AKRJ_G0030624	protein coding gene	Chr6:48647074-48724200 (-)
BALB/cJ	MGP_BALBcJ_G0030709	protein coding gene	Chr6:47329885-47406393 (-)
C3H/HeJ	MGP_C3HHeJ_G0030422	protein coding gene	Chr6:48663955-48745400 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031164	protein coding gene	Chr6:50397137-50477132 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028371	protein coding gene	Chr6:44595818-44676169 (-)
CAST/EiJ	MGP_CASTEiJ_G0029826	protein coding gene	Chr6:48371774-48450494 (-)
CBA/J	MGP_CBAJ_G0030397	protein coding gene	Chr6:52514913-52601884 (-)
DBA/2J	MGP_DBA2J_G0030546	protein coding gene	Chr6:46898702-46974387 (-)
FVB/NJ	MGP_FVBNJ_G0030498	protein coding gene	Chr6:46538842-46618345 (-)
LP/J	MGP_LPJ_G0030631	protein coding gene	Chr6:49241480-49318675 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030532	protein coding gene	Chr6:55230327-55307319 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031193	protein coding gene	Chr6:48556836-48636330 (-)
PWK/PhJ	MGP_PWKPhJ_G0029538	protein coding gene	Chr6:46467865-46547374 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029374	protein coding gene	Chr6:47882868-47960887 (-)
WSB/EiJ	MGP_WSBEiJ_G0029903	protein coding gene	Chr6:48519678-48598206 (-)

Human Ortholog

GSDME, gasdermin E

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GSDME, gasdermin E
Synonyms

DFNA5, ICERE-1
Links

HGNC:2810

NCBI Gene ID: 1687

neXtProt AC: NX_O60443

UniProt: O60443
Chr Location

7p15.3; chr7:24698355-24795539 (-) GRCh38

MGI Vertebrate Homology

Gsdme stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GSDME
Gene Tree

Gsdme

Diseases

2 with human GSDME associations

				Human Disease	Mouse Models
				autosomal dominant nonsyndromic deafness 5 IDs autosomal dominant nonsyndromic deafness 5 DOID:0110575 ICD10CM:H90.3 OMIM:600994
				sensorineural hearing loss IDs sensorineural hearing loss DOID:10003 DOID:11053 DOID:12112 DOID:12114 ICD10CM:H90.5 ICD9CM_2006:389.11 ICD9CM_2006:389.14 ICD9CM:389.1 ICD9CM:389.10 ICD9CM:389.14 MESH:D006319 NCI:C26739 UMLS_CUI:C0018784

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 3 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

11
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display abnormal numbers of cochlear hair cell but have normal hearing. Mice homozygous for another knock-out allele exhibit normal hearing but protection from chemotherapy drug-induced tissue damage and weight loss.

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All GO Annotations

37
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

779
Tissues

57
cDNA Data

9
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gsdme

ZFIN gsdmea, gsdmeb

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All Sequences

60
RefSeq

10
UniProt

7
CCDS

CCDS20130.1

Ensembl

ENSMUSG00000029821 (Evidence)
NCBI Gene

54722

			Length	Strain/Species	Flank
genomic	54722	NCBI Gene Model \| MGI Sequence Detail	73825	C57BL/6J	± kb
transcript	NM_018769	RefSeq \| MGI Sequence Detail	2135	C57BL/6
polypeptide	Q9Z2D3	UniProt \| EBI \| MGI Sequence Detail	512	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000006431 gasdermin-E

(term hierarchy)
InterPro Domains

IPR042377 Gasdermin-E

IPR040460 Gasdermin, pore forming domain

IPR041263 Gasdermin, PUB domain

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All nucleic 15

Genomic 2

cDNA 11

Primer pair 2

Microarray probesets 5

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MGD-MRK-33747, MGI:106063, MGI:1921667, MGI:1923695, MGI:3703053, MGI:5908157

Summaries

All 78

Developmental Gene Expression 6

Gene Ontology 11

Phenotypes 34
Earliest

J:32076 Guthridge MA, et al., Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts. Oncogene. 1996 Mar 21;12(6):1267-78
Latest

J:351181 Ma F, et al., Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death. Nat Commun. 2024 Jan 9;15(1):386

TSS for Gsdme:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr60901	Chr6:50238923-50238935 (-)	1,908 bp
Tssr60900	Chr6:50238771-50238793 (-)	2,055 bp
Tssr60899	Chr6:50238723-50238768 (-)	2,091 bp
Tssr1842	Chr6:50224494-50224496 (-)	16,342 bp
Tssr60898	Chr6:50222343-50222347 (-)	18,492 bp
Tssr60897	Chr6:50200094-50200138 (-)	40,721 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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