Foxo1 MGI Mouse Gene Detail - MGI:1890077 - forkhead box O1

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Foxo1 Gene Detail

Symbol

Foxo1
Name

forkhead box O1
Synonyms

Afxh, FKHR, Fkhr1, Foxo1a

Feature Type

protein coding gene
IDs

MGI:1890077
NCBI Gene: 56458
Alliance

gene page
Transcription Start Sites

5 TSS
Candidate for QTL

2 QTL

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Sequence Map

Chr3:52175758-52257530 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 23.19 cM
Mapping Data

6 experiments

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SNPs within 2kb

2142 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1890077	protein coding gene	Chr3:52175757-52260642 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027202	protein coding gene	Chr3:50796904-50885412 (+)
A/J	MGP_AJ_G0027162	protein coding gene	Chr3:49294626-49376341 (+)
AKR/J	MGP_AKRJ_G0027131	protein coding gene	Chr3:50263692-50349534 (+)
BALB/cJ	MGP_BALBcJ_G0027174	protein coding gene	Chr3:49153507-49241419 (+)
C3H/HeJ	MGP_C3HHeJ_G0026917	protein coding gene	Chr3:50498845-50583775 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027620	protein coding gene	Chr3:52811440-52897060 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024980	protein coding gene	Chr3:45907986-45989056 (+)
CAST/EiJ	MGP_CASTEiJ_G0026370	protein coding gene	Chr3:50583261-50676485 (+)
CBA/J	MGP_CBAJ_G0026894	protein coding gene	Chr3:54458005-54548517 (+)
DBA/2J	MGP_DBA2J_G0027028	protein coding gene	Chr3:48891531-48975250 (+)
FVB/NJ	MGP_FVBNJ_G0026996	protein coding gene	Chr3:47871918-47955532 (+)
LP/J	MGP_LPJ_G0027140	protein coding gene	Chr3:51543024-51630905 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027014	protein coding gene	Chr3:58612715-58699942 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027679	protein coding gene	Chr3:50195321-50282349 (+)
PWK/PhJ	MGP_PWKPhJ_G0026102	protein coding gene	Chr3:48550238-48635192 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025915	protein coding gene	Chr3:49862697-49946967 (+)
WSB/EiJ	MGP_WSBEiJ_G0026444	protein coding gene	Chr3:50306740-50389174 (+)

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Human Ortholog

FOXO1, forkhead box O1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FOXO1, forkhead box O1
Synonyms

FKH1, FKHR, FOXO1A
Links

HGNC:3819

NCBI Gene ID: 2308

neXtProt AC: NX_Q12778

UniProt: Q12778
Chr Location

13q14.11; chr13:40555667-40666641 (-) GRCh38

MGI Vertebrate Homology

Foxo1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FOXO1
Gene Tree

Foxo1

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Diseases

1 with human FOXO1 associations

				Human Disease	Mouse Models
				alveolar rhabdomyosarcoma IDs alveolar rhabdomyosarcoma DOID:4051 DOID:4382 MESH:D018232 NCI:C3749 NCI:C7958 OMIM:268220 UMLS_CUI:C0206655 UMLS_CUI:C0279613

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

3 with disease annotations

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Phenotype Summary

99 phenotypes from 13 alleles in 15 genetic backgrounds
50 phenotypes from multigenic genotypes
2 images
303 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Endonuclease-mediated

7
Gene trapped

5
Radiation induced

2
Targeted

20
Transgenic

3
Genomic Mutations

2 involving Foxo1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null embryos die at E10.5-E11.5 from vasculature defects. Heterozygote null mice have slightly elevated glycogen levels. Conditionally targeted homozygotes display hemangiomas or defects in nave T cell homeostasis depending on the targeted cell type.

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All GO Annotations

118
GO References

40

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1149
Tissues

297
cDNA Data

20
Literature Summary

98

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FOXO1

Xenbase foxo1

ZFIN foxo1a, foxo1b

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All Sequences

53
RefSeq

2
UniProt

5
CCDS

CCDS17343.1

Ensembl

ENSMUSG00000044167 (Evidence)
NCBI Gene

56458

Representative Sequences				Length	Strain/Species	Flank
	genomic	56458	NCBI Gene Model \| MGI Sequence Detail	81773	C57BL/6J	± kb
	transcript	NM_019739	RefSeq \| MGI Sequence Detail	5552	ZRU/MplStud
	polypeptide	Q9R1E0	UniProt \| EBI \| MGI Sequence Detail	652	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007640 forkhead box protein O1

(term hierarchy)
InterPro Domains

IPR047408 Forkhead box protein O1, forkhead domain

IPR001766 Fork head domain

IPR030456 Fork head domain conserved site 2

IPR032068 FOXO protein, KIX-binding domain

IPR032067 FOXO protein, transactivation domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q9R1E0 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 28

cDNA 20

Primer pair 6

Other 2

Microarray probesets 7

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MGI:2139839

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Summaries

All 642

Developmental Gene Expression 98

Diseases 3

Gene Ontology 40

Phenotypes 303
Earliest

J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
Latest

J:355125 Zhang M, et al., Foxo1 Drives the TGFbeta1-Dependent Dichotomy of Th17 Cell Fates. J Leukoc Biol. 2024 Jan 9;

TSS for Foxo1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29089	Chr3:52175795-52175809 (+)	44 bp
Tssr29090	Chr3:52175814-52175826 (+)	62 bp
Tssr29091	Chr3:52175828-52175845 (+)	79 bp
Tssr29092	Chr3:52177619-52177629 (+)	1,866 bp
Tssr29093	Chr3:52183574-52183580 (+)	7,819 bp

Foxo1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Gdfsc1	Chr3, syntenic		J:313290	QTL Gdfsc1 (GDF11 serum concentration 1) maps to Chr 3: 3.039589 - 9.983782 Mb in close proximity to the gene Hey1, a transcriptional repressor. Bioinformatic analyses located putative binding sites for the HEY1 protein upstream of the Gdf11 gene in the mouse and human genomes. While these findings indirectly support Hey1 as a candidate gene behind circulating GDF11 levels, the authors also cannot exclude other plausible genes within the same locus, such as Stathmin-2 (Stmn2). Stmn2 is another reasonable candidate as it is expressed in both murine and human heart tissue throughout development and into adulthood (Asp et al. 2019; Bult et al. 2019; Smith et al. 2019). QTL Smc1 (serum myostatin concentration 1) maps to Chr 3: 52.26269 - 52.71985 Mb. The peak is located in close proximity to protein-coding gene Forkhead Box O1 (Foxo1; MGI:1890077).
Smc1	Chr3, syntenic		J:313290	QTL Gdfsc1 (GDF11 serum concentration 1) maps to Chr 3: 3.039589 - 9.983782 Mb in close proximity to the gene Hey1, a transcriptional repressor. Bioinformatic analyses located putative binding sites for the HEY1 protein upstream of the Gdf11 gene in the mouse and human genomes. While these findings indirectly support Hey1 as a candidate gene behind circulating GDF11 levels, the authors also cannot exclude other plausible genes within the same locus, such as Stathmin-2 (Stmn2). Stmn2 is another reasonable candidate as it is expressed in both murine and human heart tissue throughout development and into adulthood (Asp et al. 2019; Bult et al. 2019; Smith et al. 2019). QTL Smc1 (serum myostatin concentration 1) maps to Chr 3: 52.26269 - 52.71985 Mb. The peak is located in close proximity to protein-coding gene Forkhead Box O1 (Foxo1; MGI:1890077).

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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