Ath11 QTL Detail

Summary

• Symbol
  Ath11
• Name
  atherosclerosis 11

• Feature Type
  QTL
• IDs
  MGI:1890352
  NCBI Gene: 492824
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Chr10:6151945-58693521 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 2 alleles in 1 genetic background
  3 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  492824

References

• Summaries
  All 8

  Phenotypes 3
• Earliest
  J:76127 Dansky HM, et al., A phenotype-sensitizing apoe-deficient genetic background reveals novel atherosclerosis predisposition Loci in the mouse. Genetics. 2002 Apr;160(4):1599-608
• Latest
  J:221553 Rodriguez JM, et al., Altered expression of Raet1e, a major histocompatibility complex class 1-like molecule, underlies the atherosclerosis modifier locus Ath11 10b. Circ Res. 2013 Oct 12;113(9):1054-64

Candidate Genes for Ath11:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Tnfaip3	Chr10:18876658-18891158 (-)	J:86703	Tnfaip3 was identified and investigated as a candidate gene for the QTL Ath11 on mouse Chromosome 10. No differences in Tnfaip3 expression level was found between parental strains FVB/N and C57BL/6J. However, sequence analysis revealed a Glu627Ala amino acid substitution between C57BL/6J and FVB/N, respectively. This functional polymorphism is thought to result in increased Nfkb inhibition in FVB/N compared to C57BL/6J.