Ankrd24 MGI Mouse Gene Detail - MGI:1890394

Symbol

Ankrd24
Name

ankyrin repeat domain 24
Synonyms

4631433D01Rik, 5730519E19Rik, D10Bur2e

Feature Type

protein coding gene
IDs

MGI:1890394
NCBI Gene: 70615
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:81464374-81483444 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

456 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890394	protein coding gene	Chr10:81464352-81483446 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017570	protein coding gene	Chr10:82366297-82385375 (+)
A/J	MGP_AJ_G0017548	protein coding gene	Chr10:79435360-79454361 (+)
AKR/J	MGP_AKRJ_G0017509	protein coding gene	Chr10:81613840-81632920 (+)
BALB/cJ	MGP_BALBcJ_G0017510	protein coding gene	Chr10:79664231-79685797 (+)
C3H/HeJ	MGP_C3HHeJ_G0017333	protein coding gene	Chr10:81721910-81744477 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017964	protein coding gene	Chr10:85184381-85203409 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015653	protein coding gene	Chr10:75630800-75650749 (+)
CAST/EiJ	MGP_CASTEiJ_G0016900	protein coding gene	Chr10:81972581-81992112 (+)
CBA/J	MGP_CBAJ_G0017305	protein coding gene	Chr10:88535450-88558857 (+)
DBA/2J	MGP_DBA2J_G0017411	protein coding gene	Chr10:78639535-78662120 (+)
FVB/NJ	MGP_FVBNJ_G0017405	protein coding gene	Chr10:77911890-77937795 (+)
LP/J	MGP_LPJ_G0017482	protein coding gene	Chr10:82818624-82837667 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017431	protein coding gene	Chr10:90351217-90372805 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018005	protein coding gene	Chr10:81632364-81652659 (+)
PWK/PhJ	MGP_PWKPhJ_G0016681	protein coding gene	Chr10:78550748-78572831 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016471	protein coding gene	Chr10:80581336-80600190 (+)
WSB/EiJ	MGP_WSBEiJ_G0016960	protein coding gene	Chr10:81682022-81703502 (+)

Human Ortholog

ANKRD24, ankyrin repeat domain 24

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANKRD24, ankyrin repeat domain 24
Links

HGNC:29424

NCBI Gene ID: 170961

neXtProt AC: NX_Q8TF21

UniProt: Q8TF21
Chr Location

19p13.3; chr19:4182689-4224814 (+) GRCh38

MGI Vertebrate Homology

Ankrd24 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANKRD24
Gene Tree

Ankrd24

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
5 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

17
Targeted

2
Transgenic

1
Genomic Mutations

1 involving Ankrd24
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

5
cDNA Data

21
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ankrd24

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All Sequences

121
RefSeq

52
UniProt

14
CCDS

CCDS36001.1

Ensembl

ENSMUSG00000054708 (Evidence)
NCBI Gene

70615

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054708	Ensembl Gene Model \| MGI Sequence Detail	19071	C57BL/6J	± kb
transcript	ENSMUST00000119336	Ensembl \| MGI Sequence Detail	3561	Not Applicable
polypeptide	ENSMUSP00000112932	Ensembl \| MGI Sequence Detail	985	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000030955 ankyrin repeat domain-containing protein 24

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR050842 Cul2-RING E3 Ligase Substrate-Recognition Fem-1

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 22

Genomic 1

cDNA 21

Microarray probesets 5

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MGI:1917865, MGI:1926000

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ankrd24:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94800	Chr10:81463525-81463576 (+)	-823 bp
Tssr94801	Chr10:81464380-81464401 (+)	17 bp
Tssr94802	Chr10:81464404-81464435 (+)	46 bp
Tssr3290	Chr10:81464516-81464523 (+)	146 bp
Tssr94803	Chr10:81464536-81464553 (+)	171 bp
Tssr94804	Chr10:81469528-81469544 (+)	5,162 bp
Tssr94805	Chr10:81479428-81479514 (+)	15,097 bp
Tssr94806	Chr10:81479631-81479690 (+)	15,287 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24