Serhl MGI Mouse Gene Detail - MGI:1890404

Symbol

Serhl
Name

serine hydrolase-like
Synonyms

1110019M09Rik

Feature Type

protein coding gene
IDs

MGI:1890404
NCBI Gene: 68607
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:82984394-83000876 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 39.32 cM
Mapping Data

2 experiments

SNPs within 2kb

512 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890404	protein coding gene	Chr15:82973707-83000876 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022157	protein coding gene	Chr15:83747576-83780248 (+)
A/J	MGP_AJ_G0022116	protein coding gene	Chr15:80693993-80729713 (+)
AKR/J	MGP_AKRJ_G0022091	protein coding gene	Chr15:83010634-83041818 (+)
BALB/cJ	MGP_BALBcJ_G0022122	protein coding gene	Chr15:80833732-80870447 (+)
C3H/HeJ	MGP_C3HHeJ_G0021892	protein coding gene	Chr15:83009554-83040252 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022567	protein coding gene	Chr15:86973547-87016257 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020091	protein coding gene	Chr15:77088299-77116388 (+)
CAST/EiJ	MGP_CASTEiJ_G0021414	protein coding gene	Chr15:83751425-83781965 (+)
CBA/J	MGP_CBAJ_G0021859	protein coding gene	Chr15:89725990-89758415 (+)
DBA/2J	MGP_DBA2J_G0021986	protein coding gene	Chr15:80195334-80223568 (+)
FVB/NJ	MGP_FVBNJ_G0021965	protein coding gene	Chr15:79229074-79257404 (+)
LP/J	MGP_LPJ_G0022057	protein coding gene	Chr15:83915021-83955169 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021985	protein coding gene	Chr15:94656508-94687423 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022582	protein coding gene	Chr15:83040510-83072528 (+)
PWK/PhJ	MGP_PWKPhJ_G0021155	protein coding gene	Chr15:80166883-80196250 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020989	protein coding gene	Chr15:82763604-82801447 (+)
WSB/EiJ	MGP_WSBEiJ_G0021463	protein coding gene	Chr15:83543127-83576125 (+)

Human Ortholog

SERHL, serine hydrolase like (pseudogene)

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERHL, serine hydrolase like (pseudogene)
Synonyms

BK126B4.1, BK126B4.2, dJ222E13.1, HS126B42
Links

HGNC:14408

NCBI Gene ID: 94009

UniProt: Q9NQF3
Chr Location

22q13.2; chr22:42500553-42512562 (+) GRCh38

Human Ortholog

SERHL2, serine hydrolase like 2
Synonyms

dJ222E13.1
Links

HGNC:29446

NCBI Gene ID: 253190

neXtProt AC: NX_Q9H4I8

UniProt: Q9H4I8
Chr Location

22q13.2; chr22:42553617-42574382 (+) GRCh38

MGI Vertebrate Homology

Serhl stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SERHL, SERHL2
Gene Tree

Serhl

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References

1 with disease annotations

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Phenotype Summary

23 phenotype references

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Serhl
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

17 strains or lines available

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

3
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SERHL

Xenbase serhl

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All Sequences

68
RefSeq

5
UniProt

7
CCDS

CCDS49682.1

Ensembl

ENSMUSG00000058586 (Evidence)
NCBI Gene

68607

			Length	Strain/Species	Flank
genomic	68607	NCBI Gene Model \| MGI Sequence Detail	16483	C57BL/6J	± kb
transcript	NM_023475	RefSeq \| MGI Sequence Detail	1391	C57BL/6
polypeptide	Q9EPB5	UniProt \| EBI \| MGI Sequence Detail	311	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000014670 serine hydrolase-like protein 2

(term hierarchy)
EC

3.1.-.-
InterPro Domains

IPR050266 AB hydrolase superfamily

IPR029058 Alpha/Beta hydrolase fold

IPR000073 Alpha/beta hydrolase fold-1

IPR051601 Serine protease/Carboxylesterase S33

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All nucleic 10

cDNA 10

Microarray probesets 3

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MGI:1915857, MGI:1918912, MGI:2143204

Summaries

All 48

Developmental Gene Expression 2

Diseases 1

Gene Ontology 4

Phenotypes 23
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:293433 Dong B, et al., Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles. Development. 2018 Oct 8;145(19):dev168468

TSS for Serhl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132408	Chr15:82984402-82984411 (+)	13 bp
Tssr132409	Chr15:82984482-82984504 (+)	99 bp
Tssr132410	Chr15:82984507-82984519 (+)	119 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24