Bwq3 QTL Detail

Summary

• Symbol
  Bwq3
• Name
  body weight, QTL 3

• Feature Type
  QTL
• IDs
  MGI:1890413
  NCBI Gene: 109384
• Candidate Genes
  2 Genes

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 8, 61.66 cM (cM position of peak correlated region/marker)
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  109384

References

• Summaries
  All 5

  Phenotypes 1
• Earliest
  J:71465 Anunciado RV, et al., Quantitative trait loci for body weight in the intercross between SM/J and A/J mice. Exp Anim. 2001 Jul;50(4):319-24
• Latest
  J:91835 Kaput J, et al., Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Physiol Genomics. 2004 Aug 11;18(3):316-24

Candidate Genes for Bwq3:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Cdh3	Chr8:107237484-107283543 (+)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 8, Es22 (43.2 cM) and Cdh3 (53.3 cM) both show differential expression between restricted and unrestricted diets on the A/a background. Diabesity QTL Wg3 (45 cM) mapsnear Es22 and diabesity QTL Bwq3 (56 cM) maps near Chd3.
Ces1e	Chr8:93927846-93956233 (-)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 8, Es22 (43.2 cM) and Cdh3 (53.3 cM) both show differential expression between restricted and unrestricted diets on the A/a background. Diabesity QTL Wg3 (45 cM) mapsnear Es22 and diabesity QTL Bwq3 (56 cM) maps near Chd3.