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Paxip1 Gene Detail
Summary
  • Symbol
    Paxip1
  • Name
    PAX interacting (with transcription-activation domain) protein 1
  • Synonyms
    D5Ertd149e, PTIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890430
    NCBI Gene: 55982
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:27945078-27996689 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 13.23 cM, cytoband A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890430
 protein coding gene Chr5:27945078-27999326 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029366
 protein coding gene Chr5:25613871-25668116 (-)
A/J MGP_AJ_G0029332
 protein coding gene Chr5:24755327-24806472 (-)
AKR/J MGP_AKRJ_G0029283
 protein coding gene Chr5:25726658-25780609 (-)
BALB/cJ MGP_BALBcJ_G0029343
 protein coding gene Chr5:25269845-25320987 (-)
C3H/HeJ MGP_C3HHeJ_G0029064
 protein coding gene Chr5:25830315-25885374 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029796
 protein coding gene Chr5:27182951-27236581 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027034
 protein coding gene Chr5:22414397-22466870 (-)
CAST/EiJ MGP_CASTEiJ_G0028475
 protein coding gene Chr5:24914247-24965881 (-)
CBA/J MGP_CBAJ_G0029032
 protein coding gene Chr5:27693761-27748475 (-)
DBA/2J MGP_DBA2J_G0029181
 protein coding gene Chr5:24983022-25035451 (-)
FVB/NJ MGP_FVBNJ_G0029139
 protein coding gene Chr5:24432487-24484010 (-)
LP/J MGP_LPJ_G0029266
 protein coding gene Chr5:26055808-26110734 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029168
 protein coding gene Chr5:28730601-28785437 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029830
 protein coding gene Chr5:25386528-25439736 (-)
PWK/PhJ MGP_PWKPhJ_G0028199
 protein coding gene Chr5:24047018-24099249 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028030
 protein coding gene Chr5:24715528-24767851 (-)
WSB/EiJ MGP_WSBEiJ_G0028555
 protein coding gene Chr5:25412142-25467181 (-)



Homology
more
  • Human Ortholog
    PAXIP1, PAX interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAXIP1, PAX interacting protein 1
  • Synonyms
    CAGF28, CAGF29, PACIP1, PAXIP1L, PTIP, TNRC2
  • Links
    NCBI Gene ID: 22976
    neXtProt AC: NX_Q6ZW49
    UniProt: Q6ZW49

  • Chr Location
    7q36.2; chr7:154943687-155003411 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 4 alleles in 4 genetic backgrounds
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are developmentally retarded and embyronic lethal by E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    99
  • cDNA Data
    9
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002221 Ensembl Gene Model | MGI Sequence Detail 51612 C57BL/6J ±  kb
    transcript ENSMUST00000002291 Ensembl | MGI Sequence Detail 5850 Not Applicable  
    polypeptide ENSMUSP00000002291 Ensembl | MGI Sequence Detail 1056 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1098588
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 16
      Phenotypes 58
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:325947 Wang Q, et al., PTIP governs NAD(+) metabolism by regulating CD38 expression to drive macrophage inflammation. Cell Rep. 2022 Mar 29;38(13):110603
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory