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Rnase2a Gene Detail
Summary
  • Symbol
    Rnase2a
  • Name
    ribonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin)
  • Synonyms
    Ear11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890465
    NCBI Gene: 93726
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51492719-51493569 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.44 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890465
 protein coding gene Chr14:51492718-51493569 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021278
 protein coding gene Chr14:45235327-45236092 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0021209
 protein coding gene Chr14:45564300-45565065 (-)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0021673
 protein coding gene Chr14:47123249-47124095 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0021180
 protein coding gene Chr14:45701905-45702670 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0021617
 protein coding gene Chr14:37357068-37357835 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0020593
 protein coding gene Chr14:45248825-45260790 (-)



Homology
more
  • Human Ortholog
    RNASE2, ribonuclease A family member 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNASE2, ribonuclease A family member 2
  • Synonyms
    EDN, RAF3, RNS2
  • Links
    NCBI Gene ID: 6036
    neXtProt AC: NX_P10153
    UniProt: P10153

  • Chr Location
    14q11.2; chr14:20955487-20956436 (+)  GRCh38
  • Human Ortholog
    RNASE3, ribonuclease A family member 3
  • Synonyms
    ECP, RAF1, RNS3
  • Links
    NCBI Gene ID: 6037
    neXtProt AC: NX_P12724
    UniProt: P12724

  • Chr Location
    14q11.2; chr14:20891385-20892348 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Genomic Mutations
    1 involving Rnase2a
  • Find Mice (IMSR)
    11 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    1
  • cDNA Data
    6
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047222 Ensembl Gene Model | MGI Sequence Detail 851 C57BL/6J ±  kb
transcript ENSMUST00000061936 Ensembl | MGI Sequence Detail 690 Not Applicable  
polypeptide ENSMUSP00000056418 Ensembl | MGI Sequence Detail 155 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR001427 Pancreatic ribonuclease
    IPR023411 Ribonuclease A, active site
    IPR023412 Ribonuclease A-domain
    IPR036816 Ribonuclease A-like domain superfamily
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:69087 Cormier SA, et al., Mouse eosinophil-associated ribonucleases: a unique subfamily expressed during hematopoiesis. Mamm Genome. 2001 May;12(5):352-61
  • Latest
    J:345920 Panova V, et al., Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11. Mucosal Immunol. 2021 Jan;14(1):26-37
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory