Laptm4b MGI Mouse Gene Detail - MGI:1890494 - lysosomal-associated protein transmembrane 4B

Symbol

Laptm4b
Name

lysosomal-associated protein transmembrane 4B
Synonyms

C330023P13Rik

Feature Type

protein coding gene
IDs

MGI:1890494
NCBI Gene: 114128
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:34238279-34284448 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 13.98 cM
Mapping Data

1 experiment

SNPs within 2kb

1245 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890494	protein coding gene	Chr15:34238174-34284448 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021776	protein coding gene	Chr15:32525868-32575576 (+)
A/J	MGP_AJ_G0021737	protein coding gene	Chr15:31288084-31335478 (+)
AKR/J	MGP_AKRJ_G0021714	protein coding gene	Chr15:32128460-32178070 (+)
BALB/cJ	MGP_BALBcJ_G0021743	protein coding gene	Chr15:31295834-31342189 (+)
C3H/HeJ	MGP_C3HHeJ_G0021518	protein coding gene	Chr15:32110502-32159786 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022182	protein coding gene	Chr15:33771678-33824064 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019720	protein coding gene	Chr15:29179190-29226753 (+)
CAST/EiJ	MGP_CASTEiJ_G0021034	protein coding gene	Chr15:32518431-32569360 (+)
CBA/J	MGP_CBAJ_G0021487	protein coding gene	Chr15:34811463-34870585 (+)
DBA/2J	MGP_DBA2J_G0021611	protein coding gene	Chr15:31094442-31142368 (+)
FVB/NJ	MGP_FVBNJ_G0021589	protein coding gene	Chr15:30548762-30595094 (+)
LP/J	MGP_LPJ_G0021680	protein coding gene	Chr15:32416045-32471105 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021614	protein coding gene	Chr15:37852021-37903848 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022205	protein coding gene	Chr15:32319589-32373257 (+)
PWK/PhJ	MGP_PWKPhJ_G0020778	protein coding gene	Chr15:31134101-31182177 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020616	protein coding gene	Chr15:32010060-32058269 (+)
WSB/EiJ	MGP_WSBEiJ_G0021090	protein coding gene	Chr15:32300115-32346879 (+)

Human Ortholog

LAPTM4B, lysosomal protein transmembrane 4 beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAPTM4B, lysosomal protein transmembrane 4 beta
Synonyms

LAPTM4beta, LC27
Links

HGNC:13646

NCBI Gene ID: 55353

neXtProt AC: NX_Q86VI4

UniProt: Q86VI4
Chr Location

8q22.1; chr8:97775057-97853013 (+) GRCh38

MGI Vertebrate Homology

Laptm4b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LAPTM4B
Gene Tree

Laptm4b

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

2
Targeted

3
Genomic Mutations

2 involving Laptm4b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects cardiomyocyte cell death, leading to exacerbation of ischemia-induced cardiac infarction.

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All GO Annotations

39
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

819
Tissues

30
cDNA Data

151
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase laptm4b

ZFIN laptm4b

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All Sequences

62
RefSeq

2
UniProt

5
CCDS

CCDS27416.1

Ensembl

ENSMUSG00000022257 (Evidence)
NCBI Gene

114128

			Length	Strain/Species	Flank
genomic	114128	NCBI Gene Model \| MGI Sequence Detail	46170	C57BL/6J	± kb
transcript	NM_033521	RefSeq \| MGI Sequence Detail	1797	C57BL/6
polypeptide	Q91XQ6	UniProt \| EBI \| MGI Sequence Detail	227	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000029588 lysosomal-associated transmembrane protein 4B

(term hierarchy)
InterPro Domains

IPR004687 Lysosomal-associated transmembrane protein 4/5

IPR051115 Lysosomal-associated transmembrane transporter

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All nucleic 152

cDNA 152

Microarray probesets 5

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MGI:1915361

Summaries

All 43

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Laptm4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131030	Chr15:34238207-34238208 (+)	-71 bp
Tssr131031	Chr15:34238254-34238323 (+)	10 bp
Tssr131032	Chr15:34238324-34238335 (+)	51 bp
Tssr131033	Chr15:34238881-34238892 (+)	608 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24