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Lin28a Gene Detail
Summary
  • Symbol
    Lin28a
  • Name
    lin-28 homolog A
  • Synonyms
    Lin-28, Lin28, Lin28a, Tex17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890546
    NCBI Gene: 83557
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:133730641-133746152 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.50 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    416 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890546
 protein coding gene Chr4:133730641-133746504 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028908
 protein coding gene Chr4:136317262-136333864 (-)
A/J MGP_AJ_G0028867
 protein coding gene Chr4:130583618-130604141 (-)
AKR/J MGP_AKRJ_G0028819
 protein coding gene Chr4:134327091-134349454 (-)
BALB/cJ MGP_BALBcJ_G0028890
 protein coding gene Chr4:131232638-131249119 (-)
C3H/HeJ MGP_C3HHeJ_G0028604
 protein coding gene Chr4:134567783-134582688 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029332
 protein coding gene Chr4:141236778-141254628 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026603
 protein coding gene Chr4:123655712-123671388 (-)
CAST/EiJ MGP_CASTEiJ_G0028037
 protein coding gene Chr4:132679059-132698883 (-)
CBA/J MGP_CBAJ_G0028569
 protein coding gene Chr4:144925824-144947883 (-)
DBA/2J MGP_DBA2J_G0028718
 protein coding gene Chr4:131015848-131035128 (-)
FVB/NJ MGP_FVBNJ_G0028686
 protein coding gene Chr4:129904014-129925910 (-)
LP/J MGP_LPJ_G0028819
 protein coding gene Chr4:136410841-136428061 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028711
 protein coding gene Chr4:149429690-149452514 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029370
 protein coding gene Chr4:134759800-134775125 (-)
PWK/PhJ MGP_PWKPhJ_G0027757
 protein coding gene Chr4:127733071-127751807 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027583
 protein coding gene Chr4:130594649-130610587 (-)
WSB/EiJ MGP_WSBEiJ_G0028116
 protein coding gene Chr4:134925058-134944559 (-)



Homology
more
  • Human Ortholog
    LIN28A, lin-28 homolog A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIN28A, lin-28 homolog A
  • Synonyms
    CSDD1, LIN-28, LIN28, lin-28A, ZCCHC1
  • Links
    NCBI Gene ID: 79727
    neXtProt AC: NX_Q9H9Z2
    UniProt: Q9H9Z2

  • Chr Location
    1p36.11; chr1:26410817-26429728 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lin28a mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 6 alleles in 10 genetic backgrounds
    9 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased birth weight and postnatal lethality. In another report, mice homozygous for the same or an identical allele exhibit reduced premordial germ cells and fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1002
  • Tissues
    173
  • cDNA Data
    28
  • Literature Summary
    55
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050966 Ensembl Gene Model | MGI Sequence Detail 15512 C57BL/6J ±  kb
    transcript ENSMUST00000051674 Ensembl | MGI Sequence Detail 3505 Not Applicable  
    polypeptide ENSMUSP00000050488 Ensembl | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 29
      Primer pair 8
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140415
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 55
      Diseases 1
      Gene Ontology 20
      Phenotypes 41
    • Earliest
      J:68614 Wang PJ, et al., An abundance of X-linked genes expressed in spermatogonia. Nat Genet. 2001 Apr;27(4):422-6
    • Latest
      J:346456 Lozovska A, et al., Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape. Nat Commun. 2024 Mar 20;15(1):2509
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory