Nek7 MGI Mouse Gene Detail - MGI:1890645 - NIMA (never in mitosis gene a)-related expressed kinase 7

Symbol

Nek7
Name

NIMA (never in mitosis gene a)-related expressed kinase 7
Synonyms

2810460C19Rik

Feature Type

protein coding gene
IDs

MGI:1890645
NCBI Gene: 59125
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr1:138411575-138547481 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 60.82 cM
Mapping Data

3 experiments

SNPs within 2kb

3720 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890645	protein coding gene	Chr1:138410613-138547879 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016547	protein coding gene	Chr1:142517495-142654865 (-)
A/J	MGP_AJ_G0016530	protein coding gene	Chr1:136987020-137124591 (-)
AKR/J	MGP_AKRJ_G0016495	protein coding gene	Chr1:141116814-141259371 (-)
BALB/cJ	MGP_BALBcJ_G0016490	protein coding gene	Chr1:137329803-137464924 (-)
C3H/HeJ	MGP_C3HHeJ_G0016316	protein coding gene	Chr1:141207170-141346716 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016951	protein coding gene	Chr1:147521618-147662434 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014662	protein coding gene	Chr1:130044750-130175693 (-)
CAST/EiJ	MGP_CASTEiJ_G0015896	protein coding gene	Chr1:140360569-140499566 (-)
CBA/J	MGP_CBAJ_G0016289	protein coding gene	Chr1:152607893-152762068 (-)
DBA/2J	MGP_DBA2J_G0016395	protein coding gene	Chr1:135985341-136117422 (-)
FVB/NJ	MGP_FVBNJ_G0016394	protein coding gene	Chr1:134633683-134763867 (-)
LP/J	MGP_LPJ_G0016466	protein coding gene	Chr1:143624742-143760484 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016419	protein coding gene	Chr1:158276039-158415298 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016987	protein coding gene	Chr1:140893962-141031018 (-)
PWK/PhJ	MGP_PWKPhJ_G0015682	protein coding gene	Chr1:135058715-135194597 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015469	protein coding gene	Chr1:139846041-139988580 (-)
WSB/EiJ	MGP_WSBEiJ_G0015959	protein coding gene	Chr1:140902871-141041763 (-)

Human Ortholog

NEK7, NIMA related kinase 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NEK7, NIMA related kinase 7
Links

HGNC:13386

NCBI Gene ID: 140609

neXtProt AC: NX_Q8TDX7

UniProt: Q8TDX7
Chr Location

1q31.3; chr1:198156994-198322420 (+) GRCh38

MGI Vertebrate Homology

Nek7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NEK7
Protein SuperFamily

Integrin-linked_kinase
Gene Tree

Nek7

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Phenotype Summary

25 phenotypes from 5 alleles in 5 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

6
Gene trapped

25
Radiation induced

1
Targeted

5
Genomic Mutations

3 involving Nek7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit infertility, decreased susceptibility to EAE, decreased body weight, abnormal gait, slight parasis and abnormal immune system response.

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All GO Annotations

54
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

980
Tissues

229
cDNA Data

14
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nek7

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All Sequences

48
RefSeq

4
UniProt

2
CCDS

CCDS15332.1, CCDS78695.1

Ensembl

ENSMUSG00000026393 (Evidence)
NCBI Gene

59125

			Length	Strain/Species	Flank
genomic	59125	NCBI Gene Model \| MGI Sequence Detail	135907	C57BL/6J	± kb
transcript	NM_021605	RefSeq \| MGI Sequence Detail	4290	ZRU/MplStud
polypeptide	Q9ES74	UniProt \| EBI \| MGI Sequence Detail	302	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011133 serine/threonine-protein kinase Nek7

(term hierarchy)
EC

2.7.11.34
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
GlyGen

Q9ES74 1 site, 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 4

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MGI:1920061, MGI:1921017, MGI:2138456

Summaries

All 73

Developmental Gene Expression 10

Gene Ontology 14

Phenotypes 23
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nek7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14046	Chr1:138547952-138547965 (-)	-478 bp
Tssr14045	Chr1:138547425-138547497 (-)	20 bp
Tssr14044	Chr1:138547403-138547421 (-)	69 bp
Tssr14043	Chr1:138547383-138547392 (-)	93 bp
Tssr14042	Chr1:138546937-138546945 (-)	540 bp
Tssr14041	Chr1:138542151-138542162 (-)	5,324 bp
Tssr14040	Chr1:138534318-138534347 (-)	13,148 bp
Tssr14039	Chr1:138526667-138526670 (-)	20,812 bp
Tssr14038	Chr1:138510108-138510117 (-)	37,368 bp
Tssr14037	Chr1:138510051-138510063 (-)	37,424 bp
Tssr14036	Chr1:138463939-138463943 (-)	83,540 bp
Tssr14035	Chr1:138421912-138421938 (-)	125,556 bp
Tssr14034	Chr1:138413059-138413064 (-)	134,419 bp
Tssr14033	Chr1:138412625-138412642 (-)	134,847 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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