Noa Gene Detail

Summary

• Symbol
  Noa
• Name
  Naruto Otsuka atrichia

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:1891009
  NCBI Gene: 170646
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Human Diseases

• Diseases
  1 with Noa mouse models

Human Disease

Mouse Models

atopic dermatitis

IDs

atopic dermatitis      

DOID:3310
EFO:0000274
ICD10CM:L20
MESH:D003876
OMIM:603165
OMIM:PS603165
UMLS_CUI:C0011615

View 1 model

Mouse Models

Human Disease Modeled: atopic dermatitis

Allelic Composition	Genetic Background	Reference	Phenotypes
Noa/Noa+	NOA	J:43274	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  16 phenotypes from 1 allele in 1 genetic background
  6 phenotype references
  

• All Mutations and Alleles
  1
• Spontaneous
  1
• Find Mice (IMSR)
  0 strains or lines available

Heterozygotes for a spontaneous mutation exhibit progressive hair loss and become hairless, ulcerative skin lesions, vibrissae abnormalities, excessive scratching, and increased mast cells and IgE levels.

Sequences &
Gene Models

• NCBI Gene
  170646

References

• Summaries
  All 7

  Diseases 1

  Phenotypes 6
• Earliest
  J:56215 Watanabe O, et al., Significantly elevated expression of PF4 (platelet factor 4) and eotaxin in the NOA mouse, a model for atopic dermatitis. J Hum Genet. 1999;44(3):173-6
• Latest
  J:208644 Shimizu Y, et al., Potentials of the circulating pruritogenic mediator lysophosphatidic Acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase d activity of autotaxin. Am J Pathol. 2014 May;184(5):1593-603