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Mtrr Gene Detail
Summary
  • Symbol
    Mtrr
  • Name
    5-methyltetrahydrofolate-homocysteine methyltransferase reductase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891037
    NCBI Gene: 210009
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:68708899-68730268 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 35.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    762 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891037
 protein coding gene Chr13:68708897-68730273 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020727
 protein coding gene Chr13:68776054-68798291 (-)
A/J MGP_AJ_G0020683
 protein coding gene Chr13:66345741-66375050 (-)
AKR/J MGP_AKRJ_G0020658
 protein coding gene Chr13:68514063-68537939 (-)
BALB/cJ MGP_BALBcJ_G0020680
 protein coding gene Chr13:66894037-66917265 (-)
C3H/HeJ MGP_C3HHeJ_G0020475
 protein coding gene Chr13:68210798-68232400 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021117
 protein coding gene Chr13:71174302-71197518 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018685
 protein coding gene Chr13:63320255-63339615 (-)
CAST/EiJ MGP_CASTEiJ_G0019992
 protein coding gene Chr13:67176732-67196583 (-)
CBA/J MGP_CBAJ_G0020433
 protein coding gene Chr13:73900964-73923014 (-)
DBA/2J MGP_DBA2J_G0020559
 protein coding gene Chr13:66247985-66269313 (-)
FVB/NJ MGP_FVBNJ_G0020539
 protein coding gene Chr13:65259698-65280965 (-)
LP/J MGP_LPJ_G0020631
 protein coding gene Chr13:69062508-69097092 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020567
 protein coding gene Chr13:72385405-72408892 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021156
 protein coding gene Chr13:67803717-67825011 (-)
PWK/PhJ MGP_PWKPhJ_G0019746
 protein coding gene Chr13:64931267-64951952 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019569
 protein coding gene Chr13:64294222-64314206 (-)
WSB/EiJ MGP_WSBEiJ_G0020049
 protein coding gene Chr13:68275928-68295873 (-)



Homology
more
  • Human Ortholog
    MTRR, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTRR, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
  • Synonyms
    cblE, MSR
  • Links
    NCBI Gene ID: 4552
    neXtProt AC: NX_Q9UBK8
    UniProt: Q9UBK8

  • Chr Location
    5p15.31; chr5:7850859-7906025 (+)  GRCh38
Human Diseases
more
  • Diseases
    17 with human MTRR associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic gene trap allele are viable and display a male-specific reduction in postnatal weight gain as well as hyperhomocysteinemia, hypomethionemia, increased tissue methyltetrahydrofolate, and AdoMet/AdoHcy ratios that range from high to slightly below normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    34
  • cDNA Data
    7
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034617 Ensembl Gene Model | MGI Sequence Detail 21370 C57BL/6J ±  kb
    transcript ENSMUST00000045827 Ensembl | MGI Sequence Detail 3692 Not Applicable  
    polypeptide ENSMUSP00000039810 Ensembl | MGI Sequence Detail 696 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000010750 methionine synthase reductase
      (term hierarchy)
    • EC
      1.16.1.8
    • InterPro Domains
      IPR017927 FAD-binding domain, ferredoxin reductase-type
      IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
      IPR001094 Flavodoxin-like
      IPR008254 Flavodoxin/nitric oxide synthase
      IPR029039 Flavoprotein-like superfamily
      IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
      IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
      IPR001433 Oxidoreductase FAD/NAD(P)-binding
      IPR017938 Riboflavin synthase-like beta-barrel
      IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 7
      Primer pair 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 27
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory