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Kcne3 Gene Detail
Summary
  • Symbol
    Kcne3
  • Name
    potassium voltage-gated channel, Isk-related subfamily, gene 3
  • Synonyms
    2210017H05Rik, MiRP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891124
    NCBI Gene: 57442
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:99825714-99834076 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.33 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    347 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891124
 protein coding gene Chr7:99825709-99834076 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032564
 protein coding gene Chr7:103041976-103050176 (+)
A/J MGP_AJ_G0032538
 protein coding gene Chr7:100456787-100464987 (+)
AKR/J MGP_AKRJ_G0032474
 protein coding gene Chr7:102843387-102851587 (+)
BALB/cJ MGP_BALBcJ_G0032549
 protein coding gene Chr7:100128786-100136986 (+)
C3H/HeJ MGP_C3HHeJ_G0032264
 protein coding gene Chr7:103212962-103221159 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033047
 protein coding gene Chr7:106961109-106969308 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030041
 protein coding gene Chr7:102860770-102868940 (+)
CAST/EiJ MGP_CASTEiJ_G0031591
 protein coding gene Chr7:94758842-94767339 (+)
CBA/J MGP_CBAJ_G0032231
 protein coding gene Chr7:110645144-110653337 (+)
DBA/2J MGP_DBA2J_G0032382
 protein coding gene Chr7:98786142-98794335 (+)
FVB/NJ MGP_FVBNJ_G0032339
 protein coding gene Chr7:98577342-98585532 (+)
LP/J MGP_LPJ_G0032472
 protein coding gene Chr7:104398771-104406971 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032372
 protein coding gene Chr7:112055881-112065458 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033069
 protein coding gene Chr7:102113648-102121835 (+)
PWK/PhJ MGP_PWKPhJ_G0031309
 protein coding gene Chr7:91890184-91898429 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031152
 protein coding gene Chr7:89421079-89430977 (+)
WSB/EiJ MGP_WSBEiJ_G0031708
 protein coding gene Chr7:102807122-102815341 (+)



Homology
more
  • Human Ortholog
    KCNE3, potassium voltage-gated channel subfamily E regulatory subunit 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNE3, potassium voltage-gated channel subfamily E regulatory subunit 3
  • Synonyms
    BRGDA6, HOKPP, HYPP, MiRP2
  • Links
    NCBI Gene ID: 10008
    neXtProt AC: NX_Q9Y6H6
    UniProt: Q9Y6H6

  • Chr Location
    11q13.4; chr11:74454841-74467729 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KCNE3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased cAMP-stimulated electrogenic Cl- secretion across tracheal and intestinal epithelia. Another knock-out allele shows age-dependent alterations in action potential and firing properties of spiral ganglion neurons in the cochlea.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    24
  • cDNA Data
    25
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57442 NCBI Gene Model | MGI Sequence Detail 8363 C57BL/6J ±  kb
    transcript NM_001360466 RefSeq | MGI Sequence Detail 1383 C57BL/6  
    polypeptide Q9WTW2 UniProt | EBI | MGI Sequence Detail 103 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000009257 potassium voltage-gated channel subfamily E member 3
      (term hierarchy)
    • InterPro Domains
      IPR000369 Potassium channel, voltage-dependent, beta subunit, KCNE
      IPR005426 Potassium channel, voltage-dependent, beta subunit, KCNE3
    • GlyGen
      Q9WTW2 3 sites
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 25
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917404
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 12
      Gene Ontology 10
      Phenotypes 24
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory