Ctsz MGI Mouse Gene Detail - MGI:1891190

Symbol

Ctsz
Name

cathepsin Z
Synonyms

cathepsin X, CTSX, D2Wsu143e

Feature Type

protein coding gene
IDs

MGI:1891190
NCBI Gene: 64138
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr2:174269287-174280832 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 97.94 cM
Mapping Data

5 experiments

SNPs within 2kb

480 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891190	protein coding gene	Chr2:174269286-174280832 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026967	protein coding gene	Chr2:180782385-180793820 (-)
A/J	MGP_AJ_G0026934	protein coding gene	Chr2:173165755-173178046 (-)
AKR/J	MGP_AKRJ_G0026905	protein coding gene	Chr2:178382375-178393826 (-)
BALB/cJ	MGP_BALBcJ_G0026943	protein coding gene	Chr2:173558483-173572689 (-)
C3H/HeJ	MGP_C3HHeJ_G0026685	protein coding gene	Chr2:178761002-178772638 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027390	protein coding gene	Chr2:185978067-185989737 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024759	protein coding gene	Chr2:166401956-166413279 (-)
CAST/EiJ	MGP_CASTEiJ_G0026144	protein coding gene	Chr2:179488333-179501287 (-)
CBA/J	MGP_CBAJ_G0026662	protein coding gene	Chr2:192907756-192919222 (-)
DBA/2J	MGP_DBA2J_G0026800	protein coding gene	Chr2:172265294-172276735 (-)
FVB/NJ	MGP_FVBNJ_G0026766	protein coding gene	Chr2:170888896-170900912 (-)
LP/J	MGP_LPJ_G0026901	protein coding gene	Chr2:180695134-180707930 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026785	protein coding gene	Chr2:195798863-195813280 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027447	protein coding gene	Chr2:178409488-178421163 (-)
PWK/PhJ	MGP_PWKPhJ_G0025880	protein coding gene	Chr2:172079081-172090519 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025680	protein coding gene	Chr2:177456546-177469151 (-)
WSB/EiJ	MGP_WSBEiJ_G0026216	protein coding gene	Chr2:179374049-179385590 (-)

Human Ortholog

CTSZ, cathepsin Z

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTSZ, cathepsin Z
Synonyms

CTSX
Links

HGNC:2547

NCBI Gene ID: 1522

neXtProt AC: NX_Q9UBR2

UniProt: Q9UBR2
Chr Location

20q13.32; chr20:58985686-59008238 (-) GRCh38

MGI Vertebrate Homology

Ctsz stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CTSZ
Gene Tree

Ctsz

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Phenotype Summary

3 phenotypes from 2 alleles in 3 genetic backgrounds
8 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Gene trapped

1
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available

No abnormal pheotype detected in homozygous mutant mice.

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All GO Annotations

27
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

8
cDNA Data

203
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctsz

ZFIN ctsz

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All Sequences

74
RefSeq

2
UniProt

3
CCDS

CCDS17152.1

Ensembl

ENSMUSG00000016256 (Evidence)
NCBI Gene

64138

			Length	Strain/Species	Flank
genomic	64138	NCBI Gene Model \| MGI Sequence Detail	11546	C57BL/6J	± kb
transcript	NM_022325	RefSeq \| MGI Sequence Detail	1454	ZRU/MplStud
polypeptide	Q9WUU7	UniProt \| EBI \| MGI Sequence Detail	306	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006035 cathepsin Z

(term hierarchy)
EC

3.4.18.1
InterPro Domains

IPR033157 Cathepsin Z

IPR025661 Cysteine peptidase, asparagine active site

IPR038765 Papain-like cysteine peptidase superfamily

IPR013128 Peptidase C1A

IPR000668 Peptidase C1A, papain C-terminal
GlyGen

Q9WUU7 4 sites, 5 N-linked glycans (1 site), 1 O-linked glycan (2 sites)

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All nucleic 206

Genomic 1

cDNA 203

Primer pair 2

Microarray probesets 5

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MGD-MRK-35814, MGI:107348, MGI:2139048, MGI:2139182

Summaries

All 62

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 17
Earliest

J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ctsz:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28031	Chr2:174280789-174280822 (-)	26 bp
Tssr28030	Chr2:174280754-174280788 (-)	61 bp
Tssr28029	Chr2:174280733-174280752 (-)	89 bp
Tssr28028	Chr2:174280690-174280731 (-)	121 bp
Tssr28027	Chr2:174280100-174280132 (-)	716 bp
Tssr28026	Chr2:174279567-174279569 (-)	1,264 bp
Tssr28025	Chr2:174275420-174275445 (-)	5,399 bp
Tssr28024	Chr2:174275341-174275365 (-)	5,479 bp
Tssr28023	Chr2:174274222-174274234 (-)	6,604 bp
Tssr28022	Chr2:174270868-174270925 (-)	9,935 bp
Tssr28021	Chr2:174270523-174270536 (-)	10,302 bp
Tssr28020	Chr2:174270485-174270498 (-)	10,340 bp
Tssr28019	Chr2:174270453-174270475 (-)	10,368 bp
Tssr28018	Chr2:174270419-174270436 (-)	10,404 bp
Tssr28017	Chr2:174269748-174269777 (-)	11,069 bp
Tssr28016	Chr2:174269671-174269683 (-)	11,155 bp
Tssr28015	Chr2:174269609-174269627 (-)	11,214 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24